Food-derived exosomes as the future of drug delivery  

作　　者：Bin Yang Miao Zhang Lixia Yue Ning Zhang Hai Wei Hongyu Zhang Bing Wang Peifeng Liu 

机构地区：[1]Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China [2]State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, China [3]School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China [4]Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China

出　　处：《Nano Research》2024年第11期9865-9886,共22页纳米研究（英文版）

基　　金：supported by the Program of Shanghai Committee of Science and Technology,China(No.22S21902900).

摘　　要：Exosomes are a kind of nanoscale membrane vesicles that can be secreted by many types of cells in both normal and pathological states and play a very important role in intercellular information exchange and transmission by transporting proteins, nucleic acids, lipids, and other biologically active substances to act on the receptor cells. Recent studies have shown that exosomes from some plants, animals, microorganisms, and other food sources can also be extracted like the structure of exosomes secreted by mammalian cells, which are named food-derived exosomes (FDEs) and can be absorbed by intestinal cells and further transported to other organs through blood circulation. With the advantages of high biocompatibility, low immunogenicity, low toxicity, high cargo capacity, and the ability to cross biological barriers, FDEs can be involved in a variety of applications such as immune response, cell migration, and tumor invasion, and have attracted a lot of attention as biotherapeutic agents and drug delivery carriers in the treatment of human diseases. This article reviews the classification, preparation characterization, physiological processes in the human body, biological functions, and application prospects of FDEs. It aims to provide a reference for the research and application of FDEs in disease treatment.

关 键 词：NANOVESICLES EXOSOMES food-derived exosomes delivery vehicles disease treatment 

分 类 号：TB383[一般工业技术—材料科学与工程]