全身炎症反应指数与初诊Ⅳ期肺癌患者营养不良风险的相关性  

Correlation analysis of systemic inflammatory response index and malnutrition risk in newly diagnosed stageⅣlung cancer patients

作　　者：施晓晓[1] 缪愿戍 张燕[2] 陈蕾[3] 张玲[3] SHI Xiaoxiao;MIAO Yuanshu;ZHANG Yan;CHEN Lei;ZHANG Ling(Department of Emergency,Nantong Tumor Hospital,Nantong,Jiangsu,China,226361;Department of Critical Medicine,Nantong Tumor Hospital,Nantong,Jiangsu,China,226361;Department of Radio-therapy,Nantong Tumor Hospital,Nantong,Jiangsu,China,226361)

机构地区：[1]南通市肿瘤医院急诊科,江苏南通226361 [2]南通市肿瘤医院重症监护室,江苏南通226361 [3]南通市肿瘤医院放疗科,江苏南通226361

出　　处：《分子诊断与治疗杂志》2024年第11期2152-2155,2160,共5页Journal of Molecular Diagnostics and Therapy

基　　金：江苏省研究型医院学会精益化用药专项科研项目(JY202233)。

摘　　要：目的探讨全身炎症反应指数(SIRI)与初诊Ⅳ期肺癌患者营养不良风险的相关性。方法选取2021年1月至2023年11月南通市肿瘤医院收治的102例初诊Ⅳ期肺癌患者作为研究对象,根据患者主观整体评估量表(PG⁃SGA)评分将102例患者分入非营养不良组(PG⁃SGA<4分,62例)和营养不良组(PG⁃SGA≥4分,40例)。收集所有患者临床资料、人口学资料及临床生化指标资料。采用Pearson相关分析探讨SIRI与PG⁃SGA评分的相关性,采用受试者工作特性(ROC)曲线评价SIRI对初诊Ⅳ期肺癌患者营养不良风险的评估价值,采用多因素Logistic回归分析探讨初诊Ⅳ期肺癌患者营养不良风险的影响因素。结果营养不良组患者SIRI高于非营养不良组,差异有统计学意义(P<0.05)。初诊Ⅳ期肺癌患者SIRI与PG⁃SGA评分呈正相关(r=0.579,P<0.001)。中性粒细胞计数、单核细胞计数、淋巴细胞计数以及SIRI评估初诊Ⅳ期肺癌患者营养不良风险的AUC(95%CI)分别为0.726(0.681~0.776)、0.813(0.763~0.862)、0.741(0.791~0.786)、0.939(0.894~0.984)。营养不良组年龄≥55岁、BMI<18.5 kg/m^(2)、月收入<2000元比例和铁蛋白水平高于非营养不良组,白蛋白水平低于非营养不良组,差异有统计学意义(P<0.05)。多因素分析显示,BMI<18.5 kg/m^(2)(OR=2.573,95%CI:1.355~4.884),月收入<2000元(OR=2.155,95%CI:1.214~3.828),SIRI≥3.1×10^(9)/L(OR=3.377,95%CI:1.772~6.436)是初诊Ⅳ期肺癌患者营养不良风险的影响因素(P<0.05)。结论高SIRI值与初诊Ⅳ期肺癌患者的营养不良风险密切相关,可作为其独立危险因素。Objective To explore the correlation between the systemic inflammatory response index(SIRI)and the risk of malnutrition in newly diagnosed patients with stageⅥlung cancer.Methods 102 newly diagnosed stageⅥlung cancer patients admitted to Nantong Cancer Hospital from February 2021 to February 2024 were selected as the research subjects.These 102 patients were divided into a non⁃malnutrition group(62 patients with a PG⁃SGA score<4 points)and a malnutrition group(40 patients with a PG⁃SGA score≥4 points)according to the Subjective Global Assessment Scale for Patients(PG⁃SGA)score.Meanwhile,the clinical data,demographic information,and clinical biochemical data of all patients were collected.Pearson correlation analysis was employed to investigate the correlation between SIRI and the PG⁃SGA score.The value of SIRI in assessing the risk of malnutrition in newly diagnosed stageⅥlung cancer patients were evaluated by ROC analysis,and the influencing factors of malnutrition risk in newly diagnosed stageⅥlung cancer patients were explored through multivariate logistic regression.Results The SIRI in the malnutrition group was higher compared to the non⁃malnutrition group,the difference is statistically significant(P<0.05).SIRI was positively correlated with the PG⁃SGA score in newly diagnosed stageⅥlung cancer patients(r=0.579,P<0.001).The AUC(95%CI)for neutrophil count,monocyte count,lymphocyte count,and SIRI in assessing of malnutrition risk in newly diagnosed stageⅥlung cancer patients were 0.726(0.681~0.776),0.813(0.763~0.862),0.741(0.791~0.786),and 0.939(0.894~0.984),respectively.The proportions of pa⁃tients aged≥55 years old,BMI<18.5 kg/m²,monthly income<2000 yuan,and ferritin level in the malnutri⁃tion group were higher than those in the non⁃malnutrition group,while the albumin level was lower than that in the non⁃malnutrition group,the difference is statistically significant(P<0.05).BMI<18.5 kg/m²(OR=2.573,95%CI:1.355~4.884),monthly income<2000 yuan(OR=2.155,95%CI:1.214~3.828

关 键 词：肺肿瘤 全身炎症反应指数 营养不良 

分 类 号：R734.2[医药卫生—肿瘤]