Transcutaneous Auricular Vagus Nerve Stimulation Ameliorates Preeclampsia-Induced Apoptosis of Placental Trophoblastic Cells Via Inhibiting the Mitochondrial Unfolded Protein Response  

作　　者：Jing Zhao Yanan Yang Jiayi Qin Siyu Tao Chunmei Jiang Huixuan Huang Qiunan Wan Yuqi Chen Shouzhu Xu Haifa Qiao 

机构地区：[1]College of Acupuncture and Tuina,Shaanxi University of Chinese Medicine,Xixian New Area,Xianyang 712046,China [2]Shaanxi Key Laboratory of Acupuncture and Medicine,Xixian New Area,Xianyang 712046,China [3]Department of Public Health,Shaanxi University of Chinese Medicine,Xixian New Area,Xianyang 712046,China [4]College of Medical Technology,Shaanxi University of Chinese Medicine,Xixian New Area,Xianyang 712046,China

出　　处：《Neuroscience Bulletin》2024年第10期1502-1518,共17页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China (82105016);the Natural Science Foundation of Shaanxi Province (2022SF-318);the Scientific Research Fund Project of Shaanxi Province Department of Education (21JSO12);the National Training Program of Innovation and Entrepreneurship for Students of China (202210716017).

摘　　要：Preeclampsia is a serious obstetric complication.Currently,there is a lack of effective preventive approaches for this disease.Recent studies have identified transcutaneous auricular vagus nerve stimulation(taVNS)as a potential novel non-pharmaceutical therapeutic modality for preeclampsia.In this study,we investigated whether taVNS inhibits apoptosis of placental trophoblastic cells through ROS-induced UPR^(mt).Our results showed that taVNS promoted the release of acetylcholine(ACh).ACh decreased the expression of UPR^(mt) by inhibiting the formation of mitochondrial ROS(mtROS),presumably through M3AChR.This reduced the release of pro-apoptotic proteins(cleaved caspase-3,NF-kB-p65,and cytochrome C)and helped preserve the morphological and functional integrity of mitochondria,thus reducing the apoptosis of placental trophoblasts,improving placental function,and relieving preeclampsia.Our study unravels the potential pathophysiological mechanism of preeclampsia.In-depth characterization of the UPR^(mt) is essential for developing more effective therapeutic strategies for preeclampsia targeting mitochondrial function.

关 键 词：PREECLAMPSIA Transcutaneous auricular vagus nerve stimulation Acetylcholine Reactive oxygen species:Mitochondrial unfolded protein response:Placental trophoblastic cells 

分 类 号：R741[医药卫生—神经病学与精神病学]