北京市西城区克-雅病监测情况调查  

Investigation on surveillance of Creutzfeldt-Jakob disease in Xicheng District of Beijing

作　　者：孟玲玉 初艳慧[1] 乔富宇[1] 魏孝侃 MENG Lingyu;CHU Yanhui;QIAO Fuyu;WEI Xiaokan(Department of Infectious Disease Prevention and Control,Beijing Xicheng District Center for Disease Control and Prevention,Beijing 100120,China)

机构地区：[1]北京市西城区疾病预防控制中心传染病预防与控制科,北京100120

出　　处：《职业与健康》2024年第16期2282-2285,共4页Occupation and Health

摘　　要：目的了解2018—2022年北京市西城区克-雅病监测病例的发病情况、流行病学特征和临床特点。方法依据《全国克-雅氏病例监测方案》,对2018—2022年北京市西城区医疗机构报告的可疑克-雅病病例的临床信息、流行病学、实验室检测结果和随访资料进行调查并对数据进行分析。结果2018—2022年北京西城区通过传染病监测预警信息系统共上报监测患者245人,最终符合克-雅病诊断标准的有145人,包括散发型克-雅病(sporadic Creutzfeldt-Jakob disease,sCJD)临床诊断病例99人,疑似诊断病例26人,遗传型克-雅病(genitic Creutzfeldt-Jakob disease,gCJD)确诊病例15人,致死性家族性失眠症(fatal familial insomnia,FFI)5人。监测病例的报告无时间聚集性,长久居住地较分散,职业分布范围较广,病例首发症状主要为快速进行性痴呆。结论2018—2022年北京市西城区通过监测预警系统上报的克-雅病病例无时空聚集性,以散发型为主,病例的报告时间、职业分布、长久居住地与散发型克-雅病的发病特点一致。近5年的流行病学特征监测情况与2014—2017年监测情况大致相同,定期随访和健康教育有助于降低二度感染风险。Objective To understand the incidence,epidemiological and clinical characteristics of Creutzfeldt-Jakob disease surveillance cases in Xicheng District of Beijing from 2018 to 2022.Methods According to the National Creutzfeldt-Jakob Case Surveillance Program,the clinical information,epidemiology,laboratory test results and follow-up data of suspected Creutzfeldt-Jakob cases reported by medical institutions in Xicheng District of Beijing from 2018 to 2022 were investigated and analyzed.Results A total of 245 patients were reported to be monitored through the infectious disease surveillance and early warning information system in Xicheng District of Beijing from 2018 to 2022.Among them,145 patients finally met the diagnostic criteria for Creutzfeldt-Jakob disease,including 99 clinically diagnosed cases of sporadic Creutzfeldt-Jakob disease(sCJD),26 suspected cases of sCJD diagnosis,15 confirmed cases of hereditary Creutzfeldt-Jakob disease(gCJD),and 5 fatal familial insomnia(FFI).The monitoring cases were not reported to have time cluster,dispersed in permanent residence and wide occupation distribution.The primary symptom of the case was rapid progressive dementia.Conclusion The cases detected in Xicheng District of Bejing from 2018 to 2022 showed no temporal and spatial aggregation,and were mainly sporadic.The reporting time,occupation distribution and long-term residence of the cases were consistent with the incidence characteristics of sporadic Creutzin-Jakob disease.Surveillance of epidemiological characteristics in the last five years was roughly the same as that from 2014 to 2017,with regular follow-up and health education helping to reduce the risk of secondary infection.

关 键 词：朊病毒病 PRNP基因 14-3-3蛋白 疾病监测 

分 类 号：R183.9[医药卫生—流行病学]