生地黄提取物及其有效成分的药理作用研究进展  

Research progress on pharmacological effects of Rehmannia glutinosa extract and its effective components

作　　者：赵婧含 李雪 吴文轩 胡建辉 段莹 武鑫华 荀思佳 马艳春[1] ZHAO Jinghan;LI Xue;WU Wenxuan;HU Jianhui;DUAN Ying;WU Xinhua;XUN Sijia;MA Yanchun(College of Basic Medical Sciences,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学基础医学院,黑龙江哈尔滨150040

出　　处：《药物评价研究》2024年第10期2443-2448,共6页Drug Evaluation Research

基　　金：黑龙江省中医药科研项目(ZYW2023-063)。

摘　　要：生地黄Rehmannia glutinosa属玄参科地黄属多年生草本植物,有清热凉血、养阴生津的功效,其所含化学成分有200余种,包括环烯醚萜类及环烯醚萜苷类、氨基酸类、紫罗兰酮类、微量元素、苯乙醇苷类、糖类等,其中地黄多糖和梓醇是生地黄的主要活性成分,具有降血糖、抗衰老、增强免疫、抗肿瘤、神经系统保护、抗抑郁、抗炎、改善骨质疏松等药理作用。主要对生地黄提取物及有效成分地黄多糖、梓醇的药理作用进行全面综述,以期为生地黄的药品开发及临床应用提供更多理论基础与依据。Rehmannia glutinosa is a perennial herb belonging to the genus Rehmannia in the family of Scrophulariaceae,which has the effect of clearing heat and cooling blood,nourishing yin and generating fluids,and contains more than 200 chemical components,including cyclic enol ether terpenes and cyclic enol ether terpene glycosides,amino acids,violet ketones,trace elements,phenyl glycosides,sugars,etc.,among which,R.glutinosa polysaccharides and catalpol are the main active ingredients of R.glutinosa and have the effects such as hypoglycemia,anti-aging,enhancement of immunity,anti-tumor,neurological protection,antidepressant,anti-inflammatory,and improvement of osteoporosis.A comprehensive review of the pharmacological effects of R.glutinosa extracts and the active ingredients R.glutinosa polysaccharides and catalpol was carried out in order to provide more theoretical basis for the development of R.glutinosa and its clinical application.

关 键 词：生地黄 梓醇 地黄多糖 抗衰老 降血糖 增强免疫 抗肿瘤 抗抑郁 

分 类 号：R285.5[医药卫生—中药学]