弥散加权成像参数联合血清LncRNA-NEAT1、miR-182-5p对脑胶质瘤术前分级的评估价值  

Value of Diffusion-Weighted Imaging Parameters Combined with Serum LncRNA-NEAT1 and miR-182-5p in the Evaluation of Preoperative Grading of Brain Glioma

作　　者：赵志永 孙其中 丁旭东 王慧敏 刘囡囡 ZHAO Zhi-yong;SUN Qi-zhong;DING Xu-dong;WANG Hui-min;LIU Nan-nan(Department of Medical Imaging,Shandong First Medical University Affiliated Provincial Hospital,Ji'nan,Shandong,250021,China)

机构地区：[1]山东第一医科大学附属省立医院医学影像科,山东济南250021

出　　处：《现代生物医学进展》2024年第20期3881-3883,共3页Progress in Modern Biomedicine

基　　金：山东省自然科学基金项目(ZR2021MH216)。

摘　　要：目的:探讨弥散加权成像(DWI)参数联合血清长链非编码核糖核酸-核富集丰富转录本1(LncRNA-NEAT1)、microRNA(miR)-182-5p对脑胶质瘤术前分级的评估价值。方法:112例脑胶质瘤患者根据术后病理分级将其分为低级别组(60例)和高级别组(52例)。术前所有患者接受DWI检查获得表观弥散系数(ADC)、相对ADC(r ADC)参数。检测脑胶质瘤患者的血清LncRNA-NEAT1、miR-182-5p表达。受试者工作特征(ROC)曲线分析DWI参数联合血清LncRNA-NEAT1、miR-182-5p诊断脑胶质瘤术前分级的价值。结果:高级别组ADC、r ADC值低于低级别组(P<0.05),血清LncRNA-NEAT1、miR-182-5p高于低级别组(P<0.05)。ADC、r ADC、LncRNA-NEAT1、miR-182-5p诊断脑胶质瘤术前高分级的曲线下面积(AUC)分别为0.834(95%CI:0.756~0.896)、0.840(95%CI:0.762~0.900)、0.784(95%CI:0.700~0.853)、0.812(95%CI:0.731~0.878),联合诊断AUC为0.959(95%CI:0.907~0.987),高于单独指标诊断。结论:高级别脑胶质瘤患者ADC、r ADC降低,血清LncRNA-NEAT1、miR-182-5p升高,联合DWI参数(ADC、r ADC)和血清LncRNA-NEAT1、miR-182-5p检测对脑胶质瘤术前分级具有较高的诊断价值。Objective:To investigate the value of diffusion-weighted imaging(DWI)parameters combined with serum long-chain non-coding ribonucleic acids-nuclear enrichment rich transcript 1(LncRNA-NEAT1)and microRNA(miR)-182-5p in the evaluation of preoperative grading of brain glioma.Methods:112 brain glioma patients were divided into low-level group(60 cases)and high-level group(52 cases)according to postoperative pathological grading.All patients underwent DWI examination before operation to obtain apparent diffusion coefficient(ADC)and relative ADC(r ADC)parameters.The expression of serum LncRNA-NEAT1 and miR-182-5p in brain glioma patients was detected.The value of DWI parameters combined with serum LncRNA-NEAT1 and miR-182-5p in the diagnosis of preoperative grading of brain glioma was analyzed by receiver operating characteristic(ROC)curve.Results:The ADC and r ADC values in high-level group were lower than those in low-level group(P<0.05),and the serum LncRNA-NEAT1 and miR-182-5p were higher than those in low-level group(P<0.05).The area under the curve(AUC)of ADC,r ADC,LncRNA-NEAT1 and miR-182-5p in the diagnosis of preoperative high-grade brain glioma was 0.834(95%CI:0.756~0.896),0.840(95%CI:0.762~0.900),0.784(95%CI:0.700~0.853),and 0.812(95%CI:0.731~0.878)respectively.AUC of combined diagnosis was 0.959(95%CI:0.907~0.987),which was higher than that of single index diagnosis.Conclusion:The ADC and r ADC of patients with high-grade brain glioma decrease,and the serum LncRNA-NEAT1 and miR-182-5p increase,the combination of DWI parameters(ADC,r ADC)and serum LncRNA-NEAT1 and miR-182-5p detection has high diagnostic value for preoperative grading of brain glioma.

关 键 词：脑胶质瘤 术前分级 弥散加权成像 LncRNA-NEAT1 miR-182-5p 

分 类 号：R739.4[医药卫生—肿瘤]