全身免疫炎症指数联合血清SCCA、VEGF-C对HPV阳性宫颈癌根治术患者术后复发风险的评估价值  

Value of Systemic Immune Inflammatory Index Combined with Serum SCCA and VEGF-C in Evaluating the Risk of Postoperative Recurrence in Patients with HPV-Positive Cervical Cancer Undergoing Radical Resection

作　　者：王俊[1] 杨天卓 李姗 李好 杜树国 WANG Jun;YANG Tian-zhuo;LI Shan;LI Hao;DU Shu-guo(Department of Medical,Wuhan University of Science and Technology School of Medicine,Wuhan,Hubei,430065,China;Department of Gynaecology and Obstetrics,Maternal and Child Health Hospital of Hubei Province,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,430070,China)

机构地区：[1]武汉科技大学医学院医学部,湖北武汉430065 [2]华中科技大学同济医学院附属湖北妇幼保健院妇产科,湖北武汉430070

出　　处：《现代生物医学进展》2024年第20期3887-3889,共3页Progress in Modern Biomedicine

基　　金：湖北省卫生和计划生育委员会联合基金项目(WJ2018H0133)。

摘　　要：目的:探讨全身免疫炎症指数(SII)联合血清鳞状细胞癌抗原(SCCA)、血管内皮生长因子-C(VEGF-C)对人乳头状瘤病毒(HPV)阳性宫颈癌根治术患者术后复发风险的评估价值。方法:选取2019年1月至2021年10月华中科技大学同济医学院附属湖北妇幼保健院收治的160例HPV阳性宫颈癌患者为研究对象,根据术后2年随访,统计复发情况,分为复发组和非复发组,对比两组临床病理资料和SII、SCCA、VEGF-C水平,采用多因素Logistic回归分析HPV阳性宫颈癌患者术后复发的影响因素。结果:复发组SII、SCCA、VEGF-C水平明显高于非复发组(P<0.05);FIGO分期、淋巴结转移、SII、SCCA、VEGF-C是HPV阳性宫颈癌患者术后复发的影响因素(P<0.05)。结论:SII及SCCA、VEGF-C在HPV阳性宫颈癌根治术复发患者中明显升高,是HPV阳性宫颈癌患者术后复发的影响因素,联合检测有助于评价患者复发风险。Objective:To investigate the value of systemic immune inflammation index(SII)combined with serum squamous cell carcinoma antigen(SCCA)and vascular endothelial growth factor-C(VEGF-C)in evaluating the risk of postoperative recurrence in patients with human papillomavirus(HPV)-positive cervical cancer undergoing radical resection.Methods:A total of 160 patients with HPV-positive cervical cancer in Maternal and Child Health Hospital of Hubei Province,Tongji Medical College,Huazhong University of Science and Technology from January 2019 to October 2021 were selected as the study subjects.According to the 2-year follow-up after operation,the recurrence was counted,and patients were divided into recurrence group and non-recurrence group,the clinicopathological data and levels of SII,SCCA and VEGF-C were compared between two groups.The influencing factors of postoperative recurrence in patients with HPV-positive cervical cancer were analyzed by multivariate Logistic regression.Results:SII,SCCA,VEGF-C in recurrence group were significantly higher than those in non-recurrence group(P<0.05).FIGO stage,lymph node metastasis,SII,SCCA,VEGF-C were the influencing factors of postoperative recurrence in patients with HPV-positive cervical cancer(P<0.05).Conclusions:SII,SCCA,and VEGF-C are significantly elevated in HPV positive cervical cancer patients with recurrence after radical surgery,and are independent factors for postoperative recurrence in HPV positive cervical cancer patients,joint testing helps evaluate the risk of recurrence in patients.

关 键 词：人乳头状瘤病毒 宫颈癌 SII SCCA VEGF-C 复发 

分 类 号：R737.33[医药卫生—肿瘤]