免疫血栓四项联合糖类抗原三项对脑梗死的预测价值及与溶栓后短期复发的关系分析  

The Predictive Value of Immune Thrombus for Cerebral Infarction and Its Relationship with Short-term Recurrence after Thrombolytic Therapy

作　　者：陈晨[1] 刘娜 孙亚楠[1] 康黎 李燕 CHEN Chen;LIU Na;SUN Ya-nan;KANG Li;LI Yan(Department of Laboratory Medicine,The Afiliated Brain Hospital of Nanjing Medical University,Nanjing,Jiangsu,210000,China)

机构地区：[1]南京医科大学附属脑科医院检验科,江苏南京210000

出　　处：《现代生物医学进展》2024年第20期3938-3940,共3页Progress in Modern Biomedicine

基　　金：江苏省卫生健康委资助项目(No.BJ21024)。

摘　　要：目的:分析免疫血栓四项联合糖类抗原三项对脑梗死的预测价值及与溶栓后短期复发的关系。方法:选择我院自2021.1至2023.1收治的105例脑梗死患者为观察组;另选同期105例健康体检者为对照组。检测所有入选者的相关指标,分析脑梗死患者免疫血栓四项及糖类抗原三项与NIHSS评分、梗死灶直径的关系,使用ROC评价免疫血栓四项、糖类抗原三项诊断脑梗死及预测其溶栓后短期复发的效能。结果:观察组免疫血栓四项和CA125水平均高于对照组(P<0.05);重度缺损患者免疫血栓四项和CA125水平均高于非重度患者(P<0.05);Pearson相关性分析患者外周血TM、TAT、PIC、CA125表达水平与NIHSS评分、梗死灶直径均呈正相关(P<0.05);ROC曲线分析外周血TM、TAT、PIC联合CA125诊断脑梗死的特异度为90.67%、敏感度为54.37%、AUC为0.925;预测溶栓后短期复发的特异度为91.27%、敏感度为53.68%、AUC为0.917。结论:TM、TAT、PIC、CA125在脑梗死患者外周血中表达上调,且与病情严重程度密切相关,联合应用可提高诊断脑梗死及预测溶栓后短期复发的效能。Objective:To analyze the predictive value of immune thrombus and carbohydrate antigen in cerebral infarction and its relationship with short-term recurrence after thrombolysis.Methods:105 patients with cerebral infarction admitted to our hospital from January 2019 to January 2019 were selected as the observation group.Another 105 healthy subjects in the same period were selected as control group.Relevant indexes of all participants were detected,and the relationship between immune thrombus and carbohydrate antigen with NIHSS score and infarct diameter in cerebral infarction patients was analyzed.ROC was used to evaluate the efficacy of immune thrombus and carbohydrate antigen in diagnosing cerebral infarction and predicting short-term recurrence after thrombolysis.Results:The levels of immune thrombus and CA125 in observation group were higher than those in control group(P<0.05).The levels of immune thrombus and CA125 in patients with severe defect were higher than those in patients without severe defect(P<0.05).The expression levels of TM,TAT,PIC and CA125 in peripheral blood of patients with cerebral infarction were positively correlated with NIHSS score and infarction diameter by Pearson correlation analysis(P<0.05).ROC curve analysis showed that the specificity,sensitivity and AUC of TM,TAT and PIC combined with CA125 in the diagnosis of cerebral infarction were 90.67%,54.37%and 0.925.The specificity,sensitivity and AUC of short-term recurrence after thrombolysis were 91.27%,53.68%and 0.917.Conclusion:The expression of TM,TAT,PIC and CA125 in peripheral blood of patients with cerebral infarction is significantly up-regulated,and is closely related to the severity of the disease.Combined application can improve the efficacy of diagnosing cerebral infarction and predicting short-term recurrence after thrombolysis.

关 键 词：脑梗死 免疫血栓四项 溶栓 复发 

分 类 号：R743[医药卫生—神经病学与精神病学]