调控线粒体生物发生改善卵母细胞质量的药物研究进展  

Advances in drug research for improving oocyte quality by regulating mitochondrial biogenesis

作　　者：厉晨雪 马瑞红[1] 刘彤瑶 田宁 张少巍 夏天[1] Li Chenxue;Ma Ruihong;Liu Tongyao;Tian Ning;Zhang Shaowei;Xia Tian(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300193,China)

机构地区：[1]天津中医药大学第一附属医院、国家中医针灸临床医学研究中心,天津300193

出　　处：《中华生殖与避孕杂志》2024年第10期1080-1084,共5页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金(82374508)。

摘　　要：线粒体在卵母细胞中具有供应能量、维持卵母细胞激活、调节钙离子稳态等作用,线粒体功能是影响卵母细胞质量的关键因素。线粒体生物发生是为满足能量需求而增加细胞线粒体质量和数量的过程,增加线粒体生物发生可有效改善卵母细胞质量。本文就能够增加线粒体生物发生的药物研究进展作一综述。Mitochondria plays an important role in supplying energy,maintaining oocyte activation,and regulating calcium homeostasis in oocytes.Mitochondrial function is a key factor affecting oocyte quality.Mitochondrial biogenesis is the process of increasing the mass and number of mitochondria in cells to meet the energy demand.Increasing mitochondrial biogenesis can effectively improve the quality of oocytes.This article reviews the research progress of drugs that can increase mitochondrial biogenesis.

关 键 词：卵母细胞 褪黑素 C型利钠肽 烟酰胺腺嘌呤二核苷酸 线粒体生物发生 白藜芦醇 辅酶Q10 虾青素 

分 类 号：R96[医药卫生—药理学]