加巴喷丁联合氟桂利嗪治疗偏头痛的疗效研究  

Study on the efficacy of gabapentin combined with flunarizine in the treatment of migraine

作　　者：张神凤 ZHANG Shenfeng(Haining Traditional Chinese Medicine Hospital,Haining 314400,China)

机构地区：[1]海宁市中医院,浙江海宁314400

出　　处：《浙江实用医学》2024年第5期375-378,385,共5页Zhejiang Practical Medicine

摘　　要：目的探讨加巴喷丁辅助氟桂利嗪治疗偏头痛的疗效。方法选择浙江省海宁市中医院2022年1月~2023年9月偏头痛患者82例,按照随机数字表法分为氟桂利嗪组和加用巴喷丁组,每组41例。氟桂利嗪组予氟桂利嗪口服治疗,10mg/次,2次/d;加用巴喷丁组在氟桂利嗪组基础上加用巴喷丁口服治疗,第1天初始剂量为0.3g;第2天为0.3g/次,2次/d;第3天0.3g/次,3次/d;第4天开始维持在0.3g/次,3次/d,并根据患者的恢复情况适当调整。两组均持续治疗1个月,并随访1个月。结果(1)临床疗效,加用巴喷丁组总有效率(95.12%)高于氟桂利嗪组(78.05%)(P<0.05);(2)焦虑与抑郁。两组SAS、SDS均较治疗前降低(均P<0.05),加用巴喷丁组较氟桂利嗪组更低(P<0.01);(3)头痛评分(SF-MPQ-2评分)。持续时间、发作频率。两组头痛评分、持续时间较治疗前降低和缩短,发作频率较治疗前下降(P<0.05),两组比较,加用巴喷丁组头痛评分更低、持续时间更短、发作频率更低(P<0.01);(4)大脑动脉血流动力学状态。两组大脑各动脉血流速度较治疗前均下降(P<0.05),两组比较,加用巴喷丁组血流速度下降更明显(P<0.01);(5)不良反应。两组各不良反应包括胃肠不适、头晕、嗜睡等发生率差异均无统计学意义(P>0.05)。结论加巴喷丁联合氟桂利嗪治疗可有效改善患者大脑动脉血流动力学状态,缩短其疼痛持续时间及发作频率,改善患者疼痛、焦虑及抑郁情况,疗效显著,安全性良好,临床应用价值较高。Objective To investigate the efficacy of gabapentin as an adjunct to flunarizine in the treatment of migraine.Method 82 migraine patients from January 2022 to September 2023 were selected from Haining Traditional Chinese Medicine Hospital in Zhejiang Province.They were randomly divided into a flunarizine group and a group treated with gabapentin,with 41 patients in each group.The Flunarizine group was treated with oral Flunarizine at a dose of 10 mg/time,twice a day;On the basis of the flunarizine group,the group treated with additional gabapentin orally,with an initial dose of 0.3g on the first day,0.3g/time,twice a day on the second day,0.3g/time,three times a day on the third day,and maintained at 0.3g/time,three times a day from the fourth day onwards,with appropriate adjustments based on the patient’s recovery.Both groups received continuous treatment for one month and were followed up for one month.Result(1)Clinical efficacy:The total effective rate of the group treated with gabapentin(95.12%)was higher than that of the group treated with flunarizine(78.05%)(P<0.05);(2)Anxiety,depression,and pain.Both groups showed a decrease in SAS、SDS and SF-MPQ-2 scores compared to before treatment(all P<0.05),with the addition of gabapentin group having a lower score than the flunarizine group(P<0.01);(3)Duration and frequency of pain.The duration of headaches in both groups was shortened compared to before treatment,and the frequency of attacks decreased compared to before treatment(P<0.05).However,compared with the two groups,the group treated with gabapentin had a shorter duration,a lower frequency of attacks,and lower SF-MPQ-2 scores(P<0.01);(4)Hemodynamic status of cerebral arteries.The blood flow velocity of each cerebral artery in both groups decreased compared to before treatment(P<0.05),and compared with the two groups,the blood flow velocity of the group treated with gabapentin decreased more significantly(P<0.01);(5)Adverse reactions.There was no statistically significant difference in the incidence of ad

关 键 词：偏头痛 氟桂利嗪 加巴喷丁 临床疗效 脑动脉血流动力学 焦虑 抑郁 

分 类 号：R747.2[医药卫生—神经病学与精神病学]