Stickler综合征相关视网膜脱离的防治研究进展  

Advances in prophylaxis and treatment of retinal detachment related to Stickler syndrome

作　　者：高谞 杨源 费萍[1] 彭婕[1] 梁庭溢 吴梦宵 赵培泉[1] Gao Xu;Yang Yuan;Fei Ping;Peng Jie;Liang Tingyi;Wu Mengxiao;Zhao Peiquan(Department of Ophthalmology,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)

机构地区：[1]上海交通大学医学院附属新华医院眼科,上海市200092

出　　处：《国际眼科杂志》2024年第12期1939-1944,共6页International Eye Science

基　　金：上海市科技计划项目(No.22015820200)。

摘　　要：Stickler综合征是一种遗传性结缔组织疾病,在眼部主要表现为高度近视和玻璃体异常,病情进展可造成巨大视网膜裂孔和孔源性视网膜脱离,是导致儿童视网膜脱离最常见的遗传性原因。Stickler综合征相关视网膜脱离主要通过手术治疗,但尚无基于循证医学证据的标准治疗指南,患者通常需经过多次手术修复,其手术复位率低、复发率高,提示预防性治疗的重要性。目前的预防方式包括巩膜扣带术、视网膜激光光凝术、视网膜冷冻术,但预防治疗的绝对获益缺乏充足的证据。文章对Stickler综合征相关视网膜脱离的预防和治疗方面的研究进展予以综述,以期为此类疾病的预防和治疗提供新思路与重要参考。Stickler syndrome is a hereditary connective tissue disorder,characterized in ocular manifestations by high myopia and vitreous abnormalities.The progression of the disease can lead to giant retinal tear and rhegmatogenous retinal detachment,making it the most common cause of inherited pediatric retinal detachment.Surgical intervention is the primary treatment for retinal detachment associated with Stickler syndrome.However,there are currently no evidence-based management strategies.Patients typically require multiple surgeries,with low reattachment rates and high recurrence rates,emphasizing the importance of prophylactic treatment.Current prophylactic measures include scleral bucking,laser photocoagulation and retinal cryotherapy,but their absolute benefits remain insufficiently supported.This review summarizes recent advances in the prophylaxis and treatment of retinal detachment in Stickler syndrome,aiming to provide new insights and essential references for the prevention and treatment for such conditions.

关 键 词：Stickler综合征 视网膜脱离 孔源性视网膜脱离 视网膜复位 预防 手术治疗 

分 类 号：R779.6[医药卫生—眼科]