圆锥角膜患者角膜交联术后角膜光密度的变化  

Changes of corneal densitometry in patients with keratoconus after corneal collagen cross-linking

作　　者：李帅 高洋 马丽梅 李瑞[2,3] 秦艺璇[4] 孙彩红 韩雨 张金金 庄文娟[3] Li Shuai;Gao Yang;Ma Limei;Li Rui;Qin Yixuan;Sun Caihong;Han Yu;Zhang Jinjin;Zhuang Wenjuan(North Minzu University,Yinchuan 750030,Ningxia Hui Autonomous Region,China;Ningxia Medical University,Yinchuan 750004,Ningxia Hui Autonomous Region,China;People's Hospital of Ningxia Hui Autonomous Region,People's Hospital of Ningxia Hui Autonomous Region,Ningxia Medical University,Ningxia Eye Hospital,Yinchuan 750002,Ningxia Hui Autonomous Region,China;Ningxia Aier Eye Hospital,Yinchuan 750011,Ningxia Hui Autonomous Region,China)

机构地区：[1]北方民族大学,宁夏回族自治区银川市750030 [2]宁夏医科大学,宁夏回族自治区银川市750004 [3]宁夏回族自治区人民医院,宁夏医科大学附属自治区人民医院、宁夏眼科医院,宁夏回族自治区银川市750002 [4]宁夏爱尔眼科医院,宁夏回族自治区银川市750011

出　　处：《国际眼科杂志》2024年第12期1954-1958,共5页International Eye Science

基　　金：北方民族大学中央高校基本科研业务费专项资金资助(No.2023XYZYX04);宁夏自然科学基金项目(No.2023AAC03450);宁夏重点研发项目(NO.2022BSB03042)。

摘　　要：目的:观察圆锥角膜患者行角膜交联术后角膜光密度的变化规律。方法:采用回顾性研究。选取2020-04/2022-04在宁夏眼科医院确诊为进展期圆锥角膜并行角膜交联术的患者32例43眼。Pentacam分析系统将角膜分为前层(前120μm)、中层及后层(后60μm),并依据直径划分为直径0-2、2-6、6-10、10-12 mm及全直径范围五个区域,测量不同范围的角膜光密度。比较术前,术后1、3、6 mo角膜光密度的变化。结果:纳入患者术前和术后6 mo裸眼视力和最佳矫正视力及眼压比较均有差异(均P<0.05),角膜内皮细胞比较无差异(P=0.477)。在角膜前层、中层、全层的直径0-2、2-6、6-10 mm及全直径范围内,角膜光密度术后1 mo时到达峰值,术后3 mo与6 mo有所下降,但仍比术前高。角膜光密度在前层及全层范围内与Kmax正相关(r=0.164,P=0.016;r=0.152,P=0.023)。结论:角膜光密度在角膜交联术后1 mo时达到峰值,随后开始逐步下降,术后6 mo趋于稳定。AIM:To observe the changes of corneal densitometry(CD)in patients with keratoconus after corneal cross-linking(CXL).METHODS:Retrospective study.A total of 32 patients(43 eyes)with keratoconus in Ningxia Eye Hospital from April 2020 to April 2022 were selected.Pentacam analysis system divided the cornea into three layers:anterior 120μm,middle layer and posterior 60μm,and divides it into five regions with diameters of 0-2,2-6,6-10,10-12 mm and full diameter according to the diameter,and measures the CD in different ranges.The changes of CD were compared before operation and at 1,3 and 6 mo after operation.RESULTS:There were differences in uncorrected visual acuity,best corrected visual acuity and intraocular pressure before and 6 mo after operation(all P<0.05),and there was no difference in corneal endothelial cells(P=0.477).CD reached its peak at 1 mo after operation,and decreased at 3 mo and 6 mo after operation,but it was still higher than that before operation.There is a significant positive correlation between CD and Kmax in the anterior layer and the whole layer(r=0.164,P=0.016;r=0.152,P=0.023).CONCLUSION:The values of CD peaked at 1 mo after CXL,then it gradually decreased,tending to become stable at 6 mo postoperatively.

关 键 词：圆锥角膜 角膜交联术 角膜光密度 

分 类 号：R779.6[医药卫生—眼科]