N-Bromosuccinimide-Promoted Direct Phosphorylation of Alcohols with P(O)-H Compounds  

N-溴代丁二酰亚胺促进的P(O)-H化合物参与的醇的直接磷酸化反应

作　　者：Wang Huabin Xu Lianhua Liu Xiongwei Pan Bowen Yao Zhen Huang Qiang Zhou Ying 王华斌;徐连华;刘雄伟;潘博文;姚震;黄强;周英(贵州中医药大学药学院,贵阳550025;遵义医科大学药学院,贵州遵义563000)

机构地区：[1]College of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550025 [2]School of Pharmacy,Zunyi Medical University,Zunyi,Guizhou 563000

出　　处：《有机化学》2024年第9期2847-2853,共7页Chinese Journal of Organic Chemistry

基　　金：贵州省中医药管理局课题(No.QZYY-2021-008);国家自然科学基金(No.82360679);贵州省基础研究(自然科学方向)(No.黔科合基础-ZK[2022]一般592)资助项目.

摘　　要：A mild,green,convenient and scalable N-bromosuccinimide(NBS)promoted direct phosphorylation strategy of secondary phosphine oxides and alcohols for the synthesis of various phosphinate esters was developed.A variety of substrates are well-tolerated and the desirable compounds were afforded in moderate to excellent yields(up to 92%).This reaction is conducted at room temperature without the addition of any oxidant and metal catalyst,which provides a new strategy for the synthesis of phosphinate esters.发展了一种温和、绿色、便捷和可扩大的N-溴代丁二酰亚胺(NBS)促进的次级膦氧化合物与醇的直接磷酸化策略,用于合成多种次磷酸酯.底物适用范围广泛且耐受性好,能以中等至优异的收率(高达92%)合成目标化合物.该反应在室温下进行,无需添加任何氧化剂和金属催化剂,为次磷酸酯衍生物的合成提供了一种新的策略.

关 键 词：PHOSPHORYLATION P—O bond phosphinate ester alcohol N-bromosuccinimide(NBS) 

分 类 号：O621.25[理学—有机化学] O627.51[理学—化学]