Ras同源基因家族蛋白A/Rho相关卷曲螺旋蛋白激酶信号通路调控缺血性卒中的研究进展  

Progress on the regulation of RhoA/ROCK signaling pathway in ischemic stroke

作　　者：张展 姜德龙[1] 王庆谚[1] 王鹏琴[2] Zhang Zhan;Jiang Delong;Wang Qingyan;Wang Pengqin(College of Traditional Chinese Medicine,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;不详)

机构地区：[1]辽宁中医药大学中医学院,沈阳110847 [2]辽宁中医药大学附属医院脑病康复二科,沈阳110847

出　　处：《中国脑血管病杂志》2024年第10期700-707,共8页Chinese Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金(82004229);沈阳市中医药专家学术经验继承项目(A10402)。

摘　　要：Ras同源基因家族蛋白A(RhoA)是一种小的鸟苷三磷酸酶蛋白,在缺血性卒中发生发展过程中可激活Rho相关卷曲螺旋蛋白激酶(ROCK)。RhoA/ROCK信号通路是缺血性卒中病理过程中的重要调节因子,调控该信号通路已成为促进缺血性卒中后神经细胞恢复和改善脑缺血-再灌注损伤的研究热点,然而目前RhoA/ROCK抑制剂仅有法舒地尔上市,其余仍处于研发或临床试验阶段。作者对RhoA/ROCK信号通路对缺血性卒中发挥的调控作用及机制进行总结,并对抑制剂及调控药物的应用进行阐述,旨在为缺血性卒中防治提供新的思路。Ras homolog gene family member A(RhoA)is a small GTPase protein.Rho-associated coiled-coil forming protein kinase(ROCK)can be activated during the occurrence and development of ischemic stroke.RhoA/ROCK signaling pathway is an important regulatory factor in the pathological process of ischemic stroke,and regulation of this signaling pathway has become a research focus in promoting neuronal recovery and improving cerebral ischemia/reperfusion injury after ischemic stroke.However,only Fasudil is currently available as a RhoA/ROCK inhibitor.The rest is still in the stage of research and development or clinical trials,and has broad research prospects.In this paper,the regulatory role and mechanism of RhoA/ROCK signaling pathway in ischemic stroke were analyzed,and the application of inhibitors and regulatory drugs were described,aiming to provide new ideas for the prevention and treatment of ischemic stroke.

关 键 词：缺血性卒中 RhoA GTP结合蛋白质 RHO相关激酶类 RhoA/ROCK信号通路 抑制剂 综述 

分 类 号：R743.3[医药卫生—神经病学与精神病学]