牙周基础治疗在重度牙周炎患者中的应用效果及对核因子-κB受体活化因子配体、骨保护素的影响  

Effect of basic periodontal therapy in patients with severe periodontitis and its influence on receptor activator of nuclear factorκB ligand and osteoprotegerin

作　　者：孙秋榕 肖庆春 刘鸣 邓炜 SUN Qiurong;XIAO Qingchun;LIU Ming;DENG Wei(Department of Stomatology,First Affiliated Hospital of Gannan Medical University,Jiangxi Province,Ganzhou 341000,China)

机构地区：[1]赣南医科大学第一附属医院口腔科,江西赣州341000

出　　处：《中国当代医药》2024年第32期82-86,共5页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(SKJP220229184)。

摘　　要：目的探讨牙周基础治疗在重度牙周炎患者中的应用效果及对核因子-κB受体活化因子配体(RANKL)、骨保护素(OPG)的影响。方法回顾性分析2020年2月至2022年1月赣南医科大学第一附属医院收治的132例(442颗)重度牙周炎患者的临床资料,根据治疗方式不同分为两组,92例(321颗)接受牙周基础治疗为观察组,40例(121颗)接受口腔卫生宣教为对照组,疗程为3个月。治疗结束后比较两组治疗效果。结果观察组治疗后血清C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)及牙周指标龈沟出血指数(SBI)、探诊深度(PD)、菌斑指数(PLI)、临床附着丧失(CAL)、RANKL水平、RANKL/OPG比值均低于对照组,差异有统计学意义(P<0.05)。观察组治疗后咀嚼效率、咬合力占最大咬合力百分比(MABF/MMF)、OPG水平均高于对照组,差异有统计学意义(P<0.05);观察组治疗后咬合时间(OT)、左右两侧咬合力平衡度(BFDB)均低于对照组,差异有统计学意义(P<0.05)。结论牙周基础治疗在控制重度牙周炎患者牙周炎症的同时可有效改善其咬合状况和咀嚼功能,疗效显著,值得推荐。Objective To investigate the effect of periodontal basic therapy in patients with severe periodontitis and its influence on receptor activator of nuclear factorκB ligand and osteoprotegerin.Methods The clinical data of 132 patients(442 patients)with severe periodontitis admitted to the First Affiliated Hospital of Gannan Medical University from February 2020 to January 2022 were retrospectively analyzed.They were divided into two groups according to different treatment methods,92 patients(321 patients)received periodontal basic treatment as the observation group,and 40 patients(121 patients)received oral health education as the control group.The course of treatment was 3 months.The therapeutic effect of the two groups was compared after treatment.Results After treatment,serum C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-17(IL-17),sulcus bleeding index(SBI),probing depth(PD),plaque index(PLI),clinical attachment loss(CAL),RANKL level and RANKL/OPG ratio in observation group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,masticatory efficiency,percentage of bite force in maximum bite force(MABF/MMF)and OPG level in observation group were higher than those in control group,the differences were statistically significant(P<0.05).After treatment,the occlusion time(OT)and percentage of bite force in maximum bite force(BFDB)in observation group were lower than those of control group,and the differences were statistically significant(P<0.05).Conclusion Periodontal basic treatment can effectively improve the occlusal status and masticatory function of patients with severe periodontitis while controlling periodontal inflammation.The curative effect is significant and worthy of recommendation.

关 键 词：牙周基础治疗 重度 牙周炎 骨保护素 核因子-ΚB受体活化因子配体 

分 类 号：R781.42[医药卫生—口腔医学]