Unraveling the epidemiology of metabolic dysfunction-associated liver cancer:Insights from mixed etiologies,regional variations,and gender disparities  

作　　者：Gong Feng Ya-Fei Fan Ru-Xin Li Giovanni Targher Christopher D.Byrne Ming-Hua Zheng 

机构地区：[1]Institute of General Practice,Xi'an Medical University,Xi'an 710021,China [2]Department of Infectious Disease,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China [3]Department of Health Management,The Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China [4]School of Clinical Medicine,Xi'an Medical University,Xi'an 710021,China [5]Department of Medicine,University of Verona,Verona 37126,Italy [6]Metabolic Diseases Research Unit,IRCCS Sacro Cuore-Don Calabria Hospital,Negrar di Valpolicella 37024,Italy [7]Southampton National Institute for Health and Care Research Biomedical Research Centre,University Hospital Southampton and University of Southampton,Southampton General Hospital,Southampton SO166YD,UK [8]MAFLD Research Center,Department of Hepatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China [9]Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province,Wenzhou 325000,China

出　　处：《iLIVER》2024年第3期57-58,共2页国际肝胆健康（英文）

基　　金：supported by grants from the Young Talent Support Program of Xi'an City Association for Science and Technology[959202413081];Scientific Research Plan Project of Shaanxi Provincial Department of Education[23JK0646];Shaanxi Province“Fourteenth Five-Year Plan”educational scientific planning project[SGH23Y2464];supported in part by the Southampton National Institute for Health and Care Research,Biomedical Research Centre[NIHR203319].

摘　　要：The Korean Republic nationwide cohort study by Yun et al.reveals a stepwise increase in hepatocellular carcinoma(HCC)risk,progressing from“pure”metabolic dysfunction-associated steatotic liver disease(MASLD)to MASLD with increased alcohol intake(MetALD)and then to alcohol-associated liver disease[1].These data also highlight the significant impact of age and gender,underscoring the importance of tailoring prevention strategies to address not only metabolic dysfunction but also alcohol consumption in liver disease management[1].This Korean cohort study also illustrates the characteristics of MASLD-related HCC,providing new insights into the natural history of this liver disease.

关 键 词：EPIDEMIOLOGY prevention GENDER 

分 类 号：R735.7[医药卫生—肿瘤]