Biomedical applications of engineered heparin-based materials  

作　　者：Ehsan Nazarzadeh Zare Danial Khorsandi Atefeh Zarepour Hulya Yilmaz Tarun Agarwal Sara Hooshmand Reza Mohammadinejad Fatma Ozdemir Onur Sahin Sevin Adiguzel Haroon Khan Ali Zarrabi Esmaeel Sharifi Arun Kumar Ebrahim Mostafavi Negar Hosseinzadeh Kouchehbaghi Virgilio Mattoli Feng Zhang Vadim Jucaud Alireza Hassani Najafabadi Ali Khademhosseini 

机构地区：[1]School of Chemistry,Damghan University,Damghan,36716-45667,Iran [2]Terasaki Institute for Biomedical Innovation,Los Angeles,CA,90024,United States [3]Department of Biomedical Engineering,Faculty of Engineering and Natural Sciences,Istinye University,Sariyer,Istanbul,34396,Turkey [4]Department of Basic Pharmacy Sciences,Faculty of Pharmacy,Istinye University,Istanbul,Turkey [5]Department of Bio-Technology,Koneru Lakshmaiah Education Foundation,Vaddeswaram,AP,India [6]Nanotechnology Research and Application Center(SUNUM),Sabanci University,Istanbul,34956,Turkey [7]Research Center of Tropical and Infectious Diseases,Kerman University of Medical Sciences,Kerman,Iran [8]Department of Pharmacy,Abdul Wali Khan University,Mardan,23200,Pakistan [9]Department of Tissue Engineering and Biomaterials,School of Advanced Medical Sciences and Technologies,Hamadan University of Medical Sciences,Hamadan,Iran [10]Institute of Polymers,Composites and Biomaterials-National Research Council(IPCB-CNR),Viale J.F.Kennedy 54-Mostra D’Oltremare pad.20,80125,Naples,Italy [11]Department of Pharmacy,School of Health Sciences,Central University of South Bihar,Gaya,824209,India [12]Department of Medicine,Stanford University School of Medicine,Stanford,CA,94305,USA [13]Stanford Cardiovascular Institute,Stanford University,School of Medicine,Stanford,CA,94305,USA [14]Istituto Italiano di Tecnologia,Centre for Materials Interfaces,Viale Rinaldo Piaggio 34,Pontedera,Pisa,56025,Italy [15]The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People’s Hospital,Quzhou,324000,Zhejiang,China

出　　处：《Bioactive Materials》2024年第1期87-118,共32页生物活性材料（英文）

基　　金：funding from the National Institutes of Health(4UG3TR003148-02,and 5R01AR073135-06);the Terasaki Institute for Biomedical Innovation.

摘　　要：Heparin is a negatively charged polysaccharide with various chain lengths and a hydrophilic backbone.Due to its fascinating chemical and physical properties,nontoxicity,biocompatibility,and biodegradability,heparin has been extensively used in different fields of medicine,such as cardiovascular and hematology.This review highlights recent and future advancements in designing materials based on heparin for various biomedical applications.The physicochemical and mechanical properties,biocompatibility,toxicity,and biodegradability of heparin are discussed.In addition,the applications of heparin-based materials in various biomedical fields,such as drug/gene delivery,tissue engineering,cancer therapy,and biosensors,are reviewed.Finally,challenges,opportunities,and future perspectives in preparing heparin-based materials are summarized.

关 键 词：HEPARIN NANOMATERIALS PHYSICOCHEMICAL BIOLOGICAL Preparation Biomedical applications 

分 类 号：R318[医药卫生—生物医学工程]