Development and preclinical evaluation of multifunctional hydrogel for precise thermal protection during thermal ablation  

作　　者：Bowen Zheng Peng Zhang Qijun Lv Tao Wu Yadong Liu Junjie Tang Yanping Ma Lili Cheng Langtao Xu Yizhen Wang Yifan Xue Jie Liu Jie Ren 

机构地区：[1]Department of Medical Ultrasonics,The Third Affiliated Hospital of Sun Yat-sen University,Guangdong Province Key Laboratory of Hepatology Research,Multiple Disciplinary Team Center of Thyroid Diseases,No.600,Tianhe Road,Guangzhou,Guangdong,510630,PR China [2]School of Biomedical Engineering,Shenzhen Campus of Sun Yat-sen University,No.66,Gongchang Road,Shenzhen,Guangdong,518107,PR China

出　　处：《Bioactive Materials》2024年第1期119-135,共17页生物活性材料（英文）

基　　金：financially supported by the National Natural Science Foundation of China(81971632,51773231);the Natural Science Foundation of Guangdong Province(2020A1515010425,2022A1515010024);Key Scientific and Technological Program of Guangzhou City(201802020023);Shenzhen Science and Technology Project(JCYJ20190807160801664,JCYJ20220818103207016).

摘　　要：Image-guided thermal ablation(TA),which is less invasive,has been widely applied for treating various kinds of tumors.However,TA still poses the potential risk of thermal damage to sensitive tissue nearby.Therefore,an adjunctive thermoprotective hydrodissection technique with constant injection of 5%glucose(5%Glu)has currently been adopted for clinical application,but this may be hazardous to humans.In this study,a multifunctional hyaluronic acid-based hydrogel(HA-Dc)was developed for hydrodissection.Compared with 5%Glu(the most clinically used solution)and the previously reported F127 hydrogel,the HA-Dc hydrogel was studied in vitro in a porcine liver model and in vivo in a rabbit model and showed good injectability and better tissue retention,stability,and thermoprotective properties throughout the TA procedure.Furthermore,in the preclinical evaluation in a Macaca fascicularis(M.fascicularis)model,HA-Dc showed excellent performance in terms of stricter neuroprotection compared with 5%Glu.In addition,the HA-Dc hydrogel with good biocompatibility and controllable degradation behavior in vivo could be a promising platform for thermal protection during clinical TA procedures.

关 键 词：Thermal ablation HYDROGELS Protection NEUROPROTECTION HYDRODISSECTION 

分 类 号：O63[理学—高分子化学]