Combination of biodegradable hydrogel and antioxidant bioadhesive for treatment of breast cancer recurrence and radiation skin injury  

作　　者：Zhuodan Zhang Qiannan Cao Yi Xia Chunyan Cui Ying Qi Qian Zhang Yuanhao Wu Jianfeng Liu Wenguang Liu 

机构地区：[1]School of Materials Science and Engineering,Tianjin Key Laboratory of Composite and Functional Materials,Tianjin University,Tianjin,300350,China [2]Key Laboratory of Radiopharmacokinetics for Innovative Drugs,Chinese Academy of Medical Sciences,Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Institute of Radiation Medicine,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin,300192,China

出　　处：《Bioactive Materials》2024年第1期408-421,共14页生物活性材料（英文）

基　　金：support for this work from the National Natural Science Foundation of China(Grant No.52233008,51733006,32301120);the CAMS Innovation Fund for Medical Sciences(2021-I2M-1-042,2021-I2M-1-060);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2022-RC350-06).

摘　　要：Postoperative radiotherapy is the standard method for inhibition of breast cancer recurrence and metastasis,whereas radiation resistant and ineluctable skin radiation injury are still key problems encountered in the prognosis of breast cancer.Herein,we design an internally implantable biodegradable hydrogel and extracutaneously applicable antioxidant bioadhesive to concurrently prevent postoperative tumor recurrence and radioactive skin injury after adjuvant radiotherapy.The biodegradable silk fibroin/perfluorocarbon hydrogel loading doxorubicin(DOX)formed by consecutive ultrasonication-inducedβ-sheets-crosslinked amphiphilic silk fibroin/perfluorocarbon/DOX nanoemulsion,exhibits continuous release of oxygen in physiological environment to improve hypoxia and sensitivity of radiotherapy,as well as simultaneous release of DOX to finally achieve effective anti-cancer effect.A stretchable bioadhesive is fabricated by copolymerization ofα-thioctic acid and N,N-diacryloyl-L-lysine,and gold nanorods and gallic acid are loaded into the bioadhesive to afford gentle photothermal therapy and antioxidant functions.The near-infrared light-induced controlled release of gallic acid and mild photothermal therapy can efficiently eliminate excess free radicals generated by radiotherapy and promote radioactive wound healing.Ultimately,in vivo animal studies substantiate the efficacy of our methodology,wherein the post-tumor resection administration of hydrogel and concomitant application of an antioxidant bioadhesive patch effectively inhibit tumor recurrence and attenuate the progression of skin radiation damage.

关 键 词：Breast cancer Biodegradable hydrogel BIOADHESIVE Adjuvant radiotherapy Radiation skin injury 

分 类 号：R737.9[医药卫生—肿瘤] TQ427.26[医药卫生—临床医学]