Nanomotor-based H_(2)S donor with mitochondrial targeting function for treatment of Parkinson’s disease  

作　　者：Zinan Zhao Lin Chen Chunhao Yang Wenyan Guo Yali Huang Wenjing Wang Mimi Wan Chun Mao Jian Shen 

机构地区：[1]National and Local Joint Engineering Research Center of Biomedical Functional Materials,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing,210023,China

出　　处：《Bioactive Materials》2024年第1期578-589,共12页生物活性材料（英文）

基　　金：supported by National Natural Science Foundation of China(No:22175096,No:22275095);Qinglan Project Foundation of Colleges and Universities of Jiangsu Province,Jiangsu Collaborative Innovation Center of Biomedical Functional Materials,Priority Academic Program Development of Jiangsu Higher Education Institution.

摘　　要：Reduction of endogenous hydrogen sulfide(H_(2)S)is considered to have an important impact on the progress of Parkinson’s disease(PD),thus exogenous H_(2)S supplementation is expected to become one of the key means to treat PD.However,at present,it is difficult for H_(2)S donors to effectively penetrate the blood brain barrier(BBB),selectively release H_(2)S in brain,and effectively target the mitochondria of neuron cells.Herein,we report a kind of nanomotor-based H_(2)S donor,which is obtained by free radical polymerization reaction between L-cysteine derivative modified-polyethylene glycol(PEG-Cys)and 2-methacryloyloxyethyl phosphorylcholine(MPC).This kind of H_(2)S donor can not only effectively break through BBB,but also be specifically catalyzed by cystathionineβ-synthase(CBS)in neurons of PD site in brain and 3-mercaptopyruvate sulfurtransferase(3-MST)in mitochondria to produce H_(2)S,endowing it with chemotaxis/motion ability.Moreover,the unique chemotaxis effect of nanomotor can realize the purpose of precisely targeting brain and the mitochondria of damaged neuron cytopathic diseases.This kind of nanomotor-based H_(2)S donor is expected to enrich the current types of H_(2)S donors and provide new ideas for the treatment of PD.

关 键 词：Hydrogen sulfide donor Mitochondrial targeting Parkinson’s disease Blood brain barrier 

分 类 号：R742.5[医药卫生—神经病学与精神病学]