奥美拉唑联合阿莫西林治疗胃炎并胃溃疡患者的效果研究  

Study on effect of omeprazole combined with amoxicillin on patients with gastritis and gastric ulcer

作　　者：王立辉 WANG Li-hui(Shenxian Zhudian Town Central Health Center,Liaocheng 252418,China)

机构地区：[1]莘县俎店镇中心卫生院,252418

出　　处：《中国现代药物应用》2024年第21期102-105,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析在胃炎并胃溃疡患者中采用奥美拉唑与阿莫西林结合治疗的临床效果。方法78例胃炎并胃溃疡患者,以随机法分为试验组和参照组,每组39例。参照组单纯采用奥美拉唑治疗,试验组采用奥美拉唑与阿莫西林联合治疗。对比两组患者临床疗效、临床症状(反酸、腹痛、胃灼烧感及嗳气饱胀)积分、胃肠激素[胃泌素(GAS)、胆囊收缩素(CCK)、胃动素(MTL)]水平。结果试验组临床总有效率97.44%高于参照组的82.05%,差异具有统计学意义(P<0.05)。治疗后,试验组反酸评分(0.68±0.13)分、腹痛评分(0.81±0.16)分、胃灼烧感评分(0.52±0.09)分、嗳气饱胀评分(0.54±0.07)分均低于参照组的(0.92±0.24)、(1.17±0.28)、(0.88±0.15)、(0.71±0.16)分,差异具有统计学意义(P<0.05)。治疗后,试验组患者GAS(70.58±6.59)ng/L、CCK(11.36±1.75)ng/L均低于参照组的(81.34±7.63)、(15.48±2.18)ng/L,MTL(231.56±15.38)ng/L高于参照组的(204.69±12.47)ng/L,差异具有统计学意义(P<0.05)。结论胃炎合并胃溃疡采用奥美拉唑联合阿莫西林治疗能有效减轻临床症状,改善胃肠激素水平,提升整体治疗效果,值得推广。Objective To analyze the clinical effect of omeprazole combined with amoxicillin on patients with gastritis and gastric ulcer.Methods 78 patients with gastritis and gastric ulcer were randomly divided into an experimental group and a reference group,with 39 cases in each group.The reference group was treated with omeprazole alone,and the experimental group was treated with omeprazole combined with amoxicillin.The clinical efficacy,clinical symptoms(acid reflux,abdominal pain,gastric sensation and belching and fullness)scores,gastrointestinal hormone levels[gastrin(GAS),cholecystokinin(CCK),motilin(MTL)]of the two groups were compared.Results The total clinical effective rate of 97.44%in the experimental group was higher than 82.05%in the reference group,and the difference was statistically significant(P<0.05).After treatment,the acid reflux score of the experimental group was(0.68±0.13)points,the abdominal pain score was(0.81±0.16)points,the gastric burning sensation score was(0.52±0.09)points and the belching and fullness score was(0.54±0.07)points,which were lower than(0.92±0.24),(1.17±0.28),(0.88±0.15)and(0.71±0.16)points of the reference group,and the difference was statistically significant(P<0.05).After treatment,the experimental group had GAS of(70.58±6.59)ng/L and CCK of(11.36±1.75)ng/L,which were lower than(81.34±7.63)and(15.48±2.18)ng/L in the reference group;MTL of(231.56±15.38)ng/L in the experimental group was higher than(204.69±12.47)ng/L in the reference group;the difference was statistically significant(P<0.05).Conclusion The combination of omeprazole and amoxicillin in the treatment of gastritis with gastric ulcer can effectively alleviate clinical symptoms,improve gastrointestinal hormone levels,and enhance overall treatment efficacy,which is worth promoting.

关 键 词：奥美拉唑 阿莫西林 胃炎 胃溃疡 

分 类 号：R573.1[医药卫生—消化系统] R573.3[医药卫生—内科学]