开塞通胶囊治疗缺血性中风病(痰瘀阻络证)的临床观察  

Clinical Study on Kaisaitong Capsules in the Treatment of Ischemic Stroke(Syndrome of Phlegm and Blood Stasis Obstructing Lung)

作　　者：成晓玲 余晖 吴平路 何泉 汪立家 Cheng Xiaoling;Yu Hui;Wu Pinglu;He Quan;Wang Lijia(Xianning Hospital of Traditional Chinese Medicine,Hubei,Xianning 437100,China)

机构地区：[1]湖北省咸宁市中医医院,湖北咸宁437100

出　　处：《中国中医急症》2024年第11期2010-2014,共5页Journal of Emergency in Traditional Chinese Medicine

基　　金：湖北省卫生健康委员会中医药科研项目(ZY2021M078)。

摘　　要：目的观察开塞通胶囊治疗缺血性中风病(IS)(痰瘀阻络证)的临床疗效。方法将90例IS(痰瘀阻络证)患者随机分为对照组与观察组,分别给予单纯西药治疗和西药+口服开塞通胶囊,治疗4周。分别于治疗前及治疗2、4周及随访4周评价中医证候积分、美国国立卫生院卒中量表(NIHSS)和日常生活活动能力(ADL)评分,评价中医证候疗效及改良Rankin量表(m RS)预后,并检测血清氧化应激指标变化。结果治疗2、4周及随访4周,观察组的中医证候评分均较治疗前显著降低(P<0.05),而对照组在随访4周时显著降低(P<0.05);观察组的中医证候积分均显著低于对照组(P<0.05)。在治疗4周及随访4周,两组的NIHSS评分均显著降低(P<0.05),且观察组的NIHSS评分显著低于对照组(P<0.05);两组的ADL评分均较治疗前显著升高(P<0.05),且观察组均较对照组升高更显著(P<0.05)。两组治疗4周后均测得超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)水平升高,而丙二醛(MDA)和氧化型低密度脂蛋白(ox-LDL)水平均降低,且观察组的改善均较对照组更显著(P<0.05)。观察组的预后良好率为64.44%,较对照组的48.89%显著升高(P<0.05)。观察组的综合疗效总有效率84.44%,显著高于对照组的71.11%(P<0.05)。结论开塞通胶囊治疗IS(痰瘀阻络证)疗效显著且安全性好,能够减轻神经功能缺损,改善ADL并减轻病残程度,其作用机制可能与抗氧化应激损伤有关。Objective:To explore the clinical efficacy of Kaisaitong Capsules in the treatment of ischemic stroke(IS)(syndrome of phlegm and blood stasis obstructing lung).Methods:A total of 90 patients with IS(syndrome of phlegm and blood stasis obstructing lung)admitted were randomly divided into a control group and an observation group.They were treated with simple western medicine and western medicine+oral administration of Kaisaitong Capsules,respectively,both with 4 weeks of treatment.Evaluations of traditional Chinese Medicine(TCM)syndrome scores,National Institutes of Health Stroke Scale(NIHSS)scores,and Activities of Daily Living(ADL)scores were performed before treatment and at 2 weeks,4 weeks,and 4 weeks after follow-up.The efficacy of TCM syndrome treatment and prognosis using the modified Rankin Scale(mRS)were assessed.Serum oxidative stress marker levels were measured before treatment and 4 weeks after treatment.Results:At 2 weeks,4 weeks,and 4 weeks follow-up after treatment,the TCM syndrome scores in the observation group were significantly lower than those before treatment(P<0.05).The control group also showed a significant decrease in TCM syndrome scores at the 4 week follow-up(P<0.05).At 4 weeks and 4 weeks after follow-up,the TCM syndrome scores in the observation group were significantly lower than those in the control group(P<0.05).At 4 weeks and 4 weeks after follow-up,the NIHSS scores in both groups were significantly reduced(P<0.05),with the observation group showing significantly lower NIHSS scores than the control group(P<0.05).At 4 weeks and 4 weeks after followup,the ADL scores in both groups were significantly higher than those before treatment(P<0.05),and the observation group showed a more significant increase in ADL scores compared with the control group(P<0.05).4 weeks after treatment,both groups showed increased levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px),and decreased levels of malondialdehyde(MDA)and oxidized low-density lipoprotein(ox-LDL),with the observation g

关 键 词：缺血性中风 开塞通胶囊 痰瘀阻络证 神经功能 氧化应激 

分 类 号：R743.3[医药卫生—神经病学与精神病学]