动态增强MRI观察肿瘤增强特点对评估微小肝癌肿瘤血供的价值  

Application value of observed tumor enhancement characteristics by dynamic enhancement MRI in assessing blood supply of small hepatocellular cancer

作　　者：孙阳 张婷婷[1] 胡晓雯 王梦莉 潘晓龙 李国荣 Sun Yang;Zhang Tingting;Hu Xiaowen;Wang Mengli;Pan Xiaolong;Li Guorong(Department of Radiology,Yichang Central People's Hospital,First Clinical Medical School of China Three Gorges University,Yichang 443000,China)

机构地区：[1]三峡大学第一临床医学院宜昌市中心人民医院放射科,宜昌443000

出　　处：《中国医学装备》2024年第11期51-56,共6页China Medical Equipment

基　　金：湖北省重点研发计划项目(20213295)。

摘　　要：目的:探讨动态增强磁共振成像(MRI)观察肿瘤增强特点对评估微小肝癌肿瘤血供的价值。方法:回顾性分析宜昌市中心人民医院2019年1月至2023年1月收治的80例疑似微小肝癌患者病例资料。所有患者通过MRI扫描仪实时观察肿瘤的增强特点,包括相对强化程度(RSI)、增强模式、时间-信号强度曲线等。记录肿瘤的增强特点,并将其与患者的病史、肿瘤类型、肿瘤大小、肿瘤数量、肝功能状态等变量进行分析。采用受试者工作特征(ROC)曲线分析动态增强MRI观察肿瘤增强特点,评估微小肝癌肿瘤血供情况的应用价值。结果:微小肝癌不同时期的动态增强MRI的RSI(F=40.151,P<0.05)、增强程度(x2=27.374,P<0.05)、时间-信号强度曲线(x2=20.950,P<0.05)比较差异均存在统计学意义,且动脉期不同增强程度的病史(F=17.844,P<0.05)、肿瘤类型(x2=11.219,P<0.05)、肿瘤大小(x2=14.081,P<0.05)、肿瘤数量(x2=74.310,P<0.05)比较差异均有统计学意义,且随着增强程度的增加,无症状期随之增加,恶性肿瘤随之增多,肿瘤大小随之增大。不同时间-信号强度曲线肝功状态的谷丙转氨酶(ALT)、谷草转氨酶(AST)和总胆红素(TBIL)比较差异均有统计学意义(F=330.182、325.872、216.689,P<0.05);动态增强MRI观察肿瘤增强特点RSI评估微小肝癌肿瘤血供情况的ROC曲线下面积(AUC)为0.582(95%CI:0.493~0.670)。结论:动态增强MRI可观察微小肝癌肿瘤血管的生成和血流动力学变化,在评估微小肝癌肿瘤血供情况方面具有一定的应用价值,可以帮助医生选择合适的治疗方案和评估治疗效果。Objective:To explore application value of observed tumor enhancement characteristics by dynamic enhancement magnetic resonance imaging(MRI)in assessing blood supply of small hepatocellular cancer.Methods:The cases data of 80 patients with suspected small hepatocellular cancer who admitted to Yichang Central People's Hospital from January 2019 to January 2023 were retrospectively analyzed.The enhancement characteristics of tumors of all patients were real-timely observed by MRI scanner,which included the relative enhancement degree(RSI),enhancement mode,time-signal intensity curve,etc.The enhanced characteristics of the tumors were recorded,which were combined with a series of variables included disease history,tumor type,tumor size,the number of tumor,liver function status of patients to conduct analysis.The receiver operating characteristics(ROC)curve was adopted to analyze the application value of the observed tumor enhancement characteristics by dynamic enhancement MRI in assessing the status of blood supply of small hepatocellular cancer.Results:There were statistically significant differences in the RSI(F=40.151,P<0.05),enhancement degree(x2=27.374,P<0.05),and time-signal intensity curve(x2=20.950,P<0.05)of dynamic enhanced MRI among different stages of small hepatocellular cancer.The differences in medical history(F=17.844,P<0.05),tumor type(x2=11.219,P<0.05),tumor size(x2=14.081,P<0.05),and the number of tumor(x2=74.310,P<0.05)among different enhancement degrees of arterial phase were also statistically significant.With the enhancement degree increased,the asymptomatic period increased,and the number of malignant tumors increased,and tumor size increased.The differences in liver function status among different time-signal intensity curves were statistically significant(F=330.182,325.872,216.689,P<0.05).The area under curve(AUC)value of the ROC of the RSI of observed tumor enhancement characteristics by dynamic enhancement MRI was 0.582(95%CI:0.493-0.670)in assessing blood supply of small hepatocellular can

关 键 词：动态增强磁共振成像 增强特点 微小肝癌 肿瘤血供 

分 类 号：R735.7[医药卫生—肿瘤] R445.2[医药卫生—临床医学]