Treatment of superficial corneal opacities with corneal stromal lenticule obtained through SMILE surgery  

作　　者：Shi-Si Hu Hui Ding Xu-Yun Meng Bo-Wen Ouyang Zhen-Duo Yang Xiao-Dan Chen Xing-Wu Zhong 

机构地区：[1]Hainan Eye Hospital and Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Haikou 570311,Hainan Province,China [2]State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou 510060,Guangdong Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第12期2221-2228,共8页国际眼科杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.82271116);Nanhai Junior Talent Program of Hainan Provincial Health Commission(No.NHXX-WJW-2023020);Hainan Province Clinical Medical Center,Science and Technology Planning Project of Hainan Province(No.ZDYF2022SHFZ326,No.LCY202406);Guangxi Health Commission Scientific Research Project(No.20170585).

摘　　要：AIM:To evaluate the clinical efficacy and feasibility of superficial corneal opacities treated by excimer laser phototherapeutic keratectomy(PTK)combined with small incision lenticule extraction(SMILE)-derived corneal stromal lenticule transplantation.METHODS:A retrospective interventional case series of nine patients aged 12-59y with superficial corneal opacity caused by different pathologies who underwent standardized PTK combined with SMILE-derived corneal stromal lenticule transplantation was examined.Lenticule patches were fixed with fibrin glue.All patients underwent pre-and post-operative clinical assessments at different times for up to 12mo.Slit lamp microscopy,corneal density,uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),and anterior segment optical coherence tomography(AS-OCT)were examined.RESULTS:The patients’mean age was 36.00±5.80(12-59)y.Seven eyes(77.8%)gained UDVA and CDVA at the last measurement compared to their preoperative levels.The densities of the total cornea,the total anterior corneal layer,and the anterior corneal layers of 0-2 and 2-6 mm decreased significantly by 12.4%,27.5%,46.7%,and 32.8%,respectively.After human allogeneic transplantation,the implanted lenticules of all eyes were clearly visible by AS-OCT and remained transparent without displacement or graft rejection.The thickness of the central cornea and corneal lenticule transplants were stable throughout the entire postoperative period.One case experienced the postoperative complication of delayed corneal epithelial healing.CONCLUSION:PTK combined with SMILE-derived corneal lenticule transplantation improves long-term visual acuity.Therefore,it is a new,safe,and effective method for treating superficial corneal opacity.

关 键 词：corneal opacity corneal lenticule TRANSPLANT phototherapeutic keratectomy 

分 类 号：R772.2[医药卫生—眼科]