Functional connectivity of paired default mode network subregions in patients with eye trauma  

作　　者：Zheng-Mao Xing Dan Song Jin-Yu Hu Xian-Mei Zhou Xuan Liao Cheng Chen Hong Wei Min Kang Qian Ling Liang-Qi He Zhen-Zhe Liu Jie Zou Xu Chen Zhen-Kai Wu Yi Shao 

机构地区：[1]Department of Ophthalmology,Nanchang People’s Hospital,Nanchang 330025,Jiangxi Province,China [2]Department of Ophthalmology,Peking University International Hospital,Beijing 102206,China [3]Department of Ophthalmology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China [4]Department of Ophthalmology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan Province,China [5]Ophthalmology Centre of Maastricht University,Maastricht 6200MS,Limburg Provincie,Netherlands [6]Changde Hospital,Xiangya School of Medicine,Central South University(the First People’s Hospital of Changde City),Changde 415000,Hunan Province,China [7]Department of Ophthalmology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,National Clinical Research Center for Eye Diseases,Shanghai 200080,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第12期2248-2255,共8页国际眼科杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China(No.82160195,No.82460203);Key R&D Program of Jiangxi Province(No.20223BBH80014);Science and Technology Project of Jiangxi Province Health Commission of Traditional Chinese Medicine(No.2022B258);Science and Technology Project of Jiangxi Health Commission(No.202210017).

摘　　要：AIM:To study functional brain abnormalities in patients with eye trauma(ET)and to discuss the pathophysiological mechanisms of ET.METHODS:Totally 31 ET patients and 31 healthy controls(HCs)were recruited.The age,gender,and educational background characteristics of the two groups were similar.After functional magnetic resonance imaging(fMRI)scanning,the subjects’spontaneous brain activity was evaluated with the functional connectivity(FC)method.Receiver operating characteristic(ROC)curve analysis was used to classify the data.Pearson’s correlation analysis was used to explore the relationship between FC values in specific brain regions and clinical behaviors in patients with ET.RESULTS:Significantly increased FC between several regions was identified including the medial prefrontal cortex(MPFC)and left hippocampus formations(HF),the MPFC and left inferior parietal lobule(IPL),the left IPL and left medial temporal lobe(MTL),the left IPL and right MTL,and the right IPL and left MTL.No decreased region-to-region connectivity was detected in default mode network(DMN)sub-regions in patients with ET.Compared with HCs,ET patients exhibited significantly increased FC between several paired DMN regions,as follows:posterior cingulate cortex(PCC)and right HF(HF.R,t=2.196,P=0.032),right inferior parietal cortices(IPC.R)and left MTL(MTL.L,t=2.243,P=0.029),and right MTL(MTL.R)and HF.R(t=2.236,P=0.029).CONCLUSION:FC values in multiple brain regions of ET patients are abnormal,suggesting that these brain regions in ET patients may be dysfunctional,which may help to reveal the pathophysiological mechanisms of ET.

关 键 词：eye trauma functional connectivity brain region 

分 类 号：R778.11[医药卫生—眼科]