Predictive value of CA-153,CA-125 and Apo A for ocular metastasis in menopausal female patients with breast cancer  

作　　者：Qun-Ce Liu Qian Ling Yan-Mei Zeng Cheng Chen Hong Wei Jin-Yu Hu Jie Zou Xiao-Yu Wang Xu Chen Yi Shao 

机构地区：[1]Department of Laboratory Medicine,Guangxin District Maternal and Child Health Hospital,Shangrao 334000,Jiangxi Province,China [2]Department of Ophthalmology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China [3]Ophthalmology Centre of Maastricht University,Maastricht 6200MS,Limburg Provincie,Netherlands [4]Department of Ophthalmology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,National Clinical Research Center for Eye Diseases,Shanghai Key Laboratory of Ocular Fundus Diseases,Shanghai Engineering Center for Visual Science and Photomedicine,Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases,Shanghai 200080,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第12期2265-2275,共11页国际眼科杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China(No.82160195,No.82460203);Jiangxi Key R&D Program of Jiangxi Province(No.20223BBH80014);Science and Technology Project of Jiangxi Province Health Commission of Traditional Chinese Medicine(No.2022B258);Science and Technology Project of Jiangxi Health Commission(No.202210017).

摘　　要：AIM:To establish a meaningful standard for diagnosing ocular metastasis(OM)in menopausal breast cancer(BC)women,and explore the relationship between CA-153,CA-125,apolipoprotein A,and OM.METHODS:A total of 1362 menopausal female BC patients with OM volunteered to take part in this study between July 2012 and July 2022.Women with BC who are menopausal were found to have an OM incidence of 1.6%.Furthermore,CA-153,CA-125,and apolipoprotein A(Apo A)all contributed to OM in women with BC who are postmenopausal according to binary logistic regression.Receiver operating curve(ROC)analysis was used to assess the diagnostic value of OM in patients with BC.RESULTS:Both CA-153 and CA-153+CA-125 showed a higher sensitivity of 95.45%,whereas CA-153+Apo A illustrated the highest specificity of 99.02%.Moreover,CA-153 and CA-153+CA-125 had higher areas under the curve(AUC)of 0.973.CONCLUSION:The data indicate that the serum concentrations of CA-153 exhibited the most significant predictors of the diagnosis of OM in menopausal women with BC.The current study researches the utility of risk factors in predicting of OM in menopausal BC women and put forward the latest suggestions on their clinical application.

关 键 词：menopausal female patients breast cancer ocular metastasis CA-125 CA-153 apolipoprotein A 

分 类 号：R779.1[医药卫生—眼科]