Monocyte to high-density lipoprotein cholesterol ratio as a predictor of the activity of thyroid-associated ophthalmopathy  

作　　者：Xing-Hong Sun Xiao-Wen Zhang Chen Han Xin Dou Xue-Ying He Meng-Ru Su Feng Jiang Song-Tao Yuan 

机构地区：[1]Department of Ophthalmology,Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing 210000,Jiangsu Province,China [2]Department of Ophthalmology,Nanjing University Medical School Affiliated Drum Tower Hospital,Nanjing 210000,Jiangsu Province,China [3]Department of Endocrinology and Metabolism,Nanjing University Medical School Affiliated Drum Tower Hospital,Nanjing 210000,Jiangsu Province,China [4]Department of Radiology,Nanjing University Medical School Affiliated Drum Tower Hospital,Nanjing 210000,Jiangsu Province,China [5]Department of Ophthalmology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第12期2276-2281,共6页国际眼科杂志（英文版）

基　　金：Supported by the Special Fund for Clinical Research of Nanjing Drum Tower Hospital(No.2023-LCYJPY-37).

摘　　要：AIM:To evaluate the relationship between monocyte to high-density lipoprotein cholesterol ratio(MHR)and the disease activity of thyroid-associated ophthalmopathy(TAO).METHODS:A total of 87 patients were classified into two groups based on clinical activity score(CAS)scoring criteria:high CAS group(n=62,the CAS score was≥3);low CAS group(n=25,the CAS score was<3).In addition,a group of healthy people(n=114)were included to compared the MHR.Proptosis,MHR,average signal intensity ratio(SIR),average lacrimal gland(LG)-SIR,average extraocular muscles(EOM)area from 87 patients with TAO were calculated in magnetic resonance imaging(MRI),and compared between these two groups.Correlation testing was utilized to evaluate the association of parameters among the clinical variables.RESULTS:Patients in high CAS group had a higher proptosis(P=0.041)and MHR(P=0.048).Compared to the healthy group,the MHR in the TAO group was higher(P=0.001).Correlation testing declared that CAS score was strongly associated with proptosis and average SIR,and MHR was positively associated with CAS score,average SIR,and average LG-SIR.The area under the receiver operating characteristic curve(AUC)of MHR was 0.6755.CONCLUSION:MHR,a novel inflammatory biomarker,has a significant association with CAS score and MRI imaging(average SIR and LG-SIR)and it can be a new promising predictor during the active phase of TAO.

关 键 词：thyroid-associated ophthalmopathy monocyte to high-density lipoprotein cholesterol ratio disease activity 

分 类 号：R771.3[医药卫生—眼科]