神经肌肉阻滞剂的研究进展  

Research progress of neuromuscular blocking agents

作　　者：张毅 吴锦慧[2] 许向阳[1] ZHANG Yi;WU Jinhui;XU Xiangyang(Jiangsu Key Laboratory of Central Nervous System Drug Research and Development,Jiangsu Nhwa Pharmaceutical Co.,Ltd.,Xuzhou 221116,China;School of Medicine,Nanjing University,Nanjing 210093,China)

机构地区：[1]江苏恩华药业股份有限公司,江苏省中枢神经药物研究重点实验室,江苏徐州221116 [2]南京大学医学院,江苏南京210093

出　　处：《中国药物化学杂志》2024年第5期398-408,共11页Chinese Journal of Medicinal Chemistry

基　　金：江苏省卓越博士后计划资助项目(2023ZB462)。

摘　　要：神经肌肉阻滞剂(NMBAs)也称肌肉松弛药,可阻断兴奋在神经肌肉接头的传递而引起相关肌肉麻痹。临床上,NMBAs常用于辅助气管插管和机械通气,也在多种外科手术中用于维持肌肉松弛状态。本文作者总结了近年来NMBAs的研究进展,结合化合物结构特征分析了不同化合物的药效特点,讨论了当前研究中面临的问题,并对今后的研究方向进行了展望,以期为新型NMBAs的研发提供参考。Neuromuscular blocking agents(NMBAs),also known as muscle relaxants,which can disrupt the synaptic transmission at neuromuscular junctions and thus induce muscle paralysis.In clinical practice,NMBAs are commonly used to assist tracheal intubation and mechanical ventilation,and provide relaxation of skeletal muscles during surgery.In this paper,the research progress of NMBAs in recent years was summarized,their pharmacological characteristics according to the structural features of the compounds were analyzed,the problems faced in current research were discussed,and a prospect to the research directions in the future was given.This review will serve as a reference for the research and development of new NMBAs.

关 键 词：神经肌肉阻滞剂 肌肉松弛药 烟碱型乙酰胆碱受体 构效关系 

分 类 号：R914[医药卫生—药物化学]