肠道微生物群与胆囊结石形成的相关性研究进展  

Progress in the study of the correlation between intestinal microbiota and gallbladder stone formation

作　　者：李勇利 薛荣泉 孙玥彤 LI Yongli;XUE Rongquan;SUN Yuetong(Inner Mongolia Clinical Medical College,Inner Mongolia Medical University,Hohhot 010017,China;Department of Hepatobiliary,Pancreatic,and Spleen Surgery,Inner Mongolia Autonomous Region People's Hospital,Hohhot 010017,China;Inner Mongolia Academy of Medical Sciences,Hohhot 010017,China)

机构地区：[1]内蒙古医科大学内蒙古临床医学院,呼和浩特010017 [2]内蒙古自治区人民医院肝胆胰脾外科,呼和浩特010017 [3]内蒙古医学科学院,呼和浩特010017

出　　处：《国际免疫学杂志》2024年第5期554-560,共7页International Journal of Immunology

基　　金：内蒙古自治区科技计划项目(2021GG0116);内蒙古自治区公立医院科研联合基金科技项目(2023GLLH0021)。

摘　　要：胆囊结石是世界范围内最常见的消化系统疾病,随着我国社会发展,其发病率也逐年上升,与胆囊结石形成相关的多种危险因素包括但不限于遗传、饮食习惯、生活方式改变和各种药物,但是其形成机制仍然有待研究。人类可以被认为是"超级有机体",肠道微生物群是与宿主共同进化的"虚拟器官",存在于人类胃肠道中,形成了一个巨大的微生物生态系统,容纳了数万亿个微生物细胞,是人体密不可分的一部分,相关研究表明,肠道微生物与胆囊结石的形成存在一定的相关性,文章就肠道微生物群与胆囊结石形成机制的相关性研究进展进行综述。Gallbladder stones are the most common digestive disease worldwide,and their incidence has been increasing year by year with the development of our society.A variety of risk factors associated with the formation of gallbladder stones include,but are not limited to,heredity,dietary habits,lifestyle changes,co-morbidities,and a variety of medications,but the mechanism of their formation remains to be studied.Human beings can be considered as"superorganisms",and the gut microbiota is a"virtual organ"that has co-evolved with the host.The gastrointestinal tract is a huge microbial ecosystem that contains trillions of microbial cells and is an inseparable part of the human body;relevant studies have shown that there is a certain correlation between gut microbes and the formation of gallbladder stones;therefore,this review will summarized the progress of the research on the correlation between the gut microbiota and the mechanism of the formation of gallbladder stones.

关 键 词：肠道微生物群 胆囊结石 胆汁酸代谢 细菌定植 

分 类 号：R575.62[医药卫生—消化系统]