Nickel-catalyzed regiodivergent syn-hydrosilylation of disubstituted alkynes  

镍催化非对称内炔烃的区域发散式氢硅化构建烯基硅烷

作　　者：Jixin Wang Jie Lin Zhili Cui Jianlin Yao Konstantin Karaghiosoff Jie Li 王吉鑫;林杰;崔志立;姚建林;Konstantin Karaghiosoff;李杰

机构地区：[1]Key Laboratory of Organic Synthesis of Jiangsu Province,Suzhou Key Laboratory of Pathogen Bioscience and Anti-infective Medicine,College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou 215123,China [2]Department Chemie,Ludwig-Maximilians-Universität München,Munich 81377,Germany

出　　处：《Science Bulletin》2024年第21期3334-3339,共6页科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(22322108);Natural Science Foundation of Jiangsu Province(BK20231521 and BK20221355);Jiangsu Specially Appointed Professors Plan(SR10900122),and start-up funds from Soochow University.

摘　　要：Given the importance of alkenylsilanes in organosilicon chemistry and material science, direct transition-metal-catalyzed selective hydrosilylation of alkynes with hydrosilanes has emerged as apowerful platform for accessing such building blocks in a straightforwardand atom-economical fashion [1,2]. Among them,regio- and stereoselective hydrosilylations of terminal alkynesand symmetrical internal alkynes have been thoroughly studied,and a range of 3d transition-metal catalysts exhibited excellentb-(E), b-(Z), and a-selectivity in these transformations [3–9].Despite these major advances, crucial drawbacks exist in thecatalytic hydrosilylation between hydrosilanes and unsymmetricalinternal alkynes, particularly when done in a regiodivergent andstereocontrolled fashion. The representative examples are largelyrestricted to the use of electronically [10] or sterically [11] biasedalkynes (Fig. 1a).

关 键 词：CATALYZED ALKYNES SUBSTITUTED 

分 类 号：O627.41[理学—有机化学]