粪便隐血联合粪便钙卫蛋白检测在克罗恩病与肠易激综合征辅助鉴别中的意义  

Significance of Fecal Occult Blood Combined with Fecal Calvetin Detection in Differentiating Crohn's Disease from Irritable Bowel Syndrome

作　　者：王婧凯 饶姣玥 WANG Jing-kai;RAO Jiao-yue(Department of Clinical Laboratory,First Affiliated Hospital of Nanyang Medical College,Nanyang,Henan473000)

机构地区：[1]南阳医学高等专科学校第一附属医院检验科,河南南阳473000

出　　处：《中国肛肠病杂志》2024年第10期37-40,共4页Chinese Journal of Coloproctology

摘　　要：目的:探讨粪便隐血联合粪便钙卫蛋白检测在克罗恩病与肠易激综合征辅助鉴别中的意义。方法:回顾性分析2022年4月至2023年10月在我院确诊为克罗恩病或肠易激综合征患者88例,其中克罗恩病组39例、肠易激综合征组49例,同时选取于我院体检结果正常的健康者88名为对照组。分别采集所有研究者的粪便样本,检测粪便隐血阳性率、粪便钙卫蛋白(FC)水平,并采用受试者工作特征曲线(ROC)评价分析粪便隐血阳性率、FC水平单项检测与联合检测对克罗恩病和肠易激综合征的诊断鉴别价值。结果:克罗恩病组患者FC水平和粪便隐血阳性率均高于肠易激综合征组、对照组,肠易激综合征组高于对照组(P<0.05)。根据ROC曲线显示,FC水平和粪便隐血阳性率单项检测与联合检测鉴别克罗恩病和肠易激综合征的AUC分别为0.895、0.788、0.950,灵敏度分别为79.5%、71.8%、92.3%,特异度分别81.6%、85.7%、83.7%,可知相比单项检测,联合检测的鉴别价值较高。结论:粪便隐血、FC检测可辅助临床鉴别克罗恩病与肠易激综合征,且联合检测临床价值更高,能够为临床诊断提供相关支持。Objective To investigate the significance of fecal occult blood(FOB)combined with fecal calvetin(FC)detection in the differentiating Crohn's disease from irritable bowel syndrome.Methods A retrospective analysis was performed on 88 patients diagnosed with Crohn's disease or irritable bowel syn-drome in our hospital from April 2022 to October 2023,including 39 patients in the Crohn's disease group and 49 patients in the irritable bowel syndrome group,and 88 healthy patients with normal physical exami-nation results in our hospital were selected as the control group.Fecal samples of all subjects were collect-ed to detect the positive rate of FOB and FC level.Receiver operating characteristic curve(ROC)was used to analyze the diagnostic and differential value of separate detection and combined detection of positive rate of FOB and FC level in Crohn's disease and irritable bowel syndrome.Results The FC level and positive rate of FOB in the Crohn's disease group were higher than those in the irritable bowel syndrome group and control group,which were higher in the irritable bowel syndrome group than in the control group(P<0.05).According to the ROC curve,the AUC of FC level and positive rate of FOB for differentiating Crohn's disease from irritable bowel syndrome were 0.895,0.788 and 0.950,respectively,with sensitivity of 79.5%,71.8%and 92.3%,and specificity of 81.6%,85.7%and 83.7%,respectively.Compared with the separate detection,the combined detection has higher differentiation value.Conclusion FOB and FC detection can assist clinical differentiation of Crohn's disease and irritable bowel syndrome,and the com-bined detection has higher clinical value,and can provide relevant support for clinical diagnosis.

关 键 词：克罗恩病 肠易激综合征 粪便隐血 粪便钙卫蛋白 鉴别诊断 

分 类 号：R574[医药卫生—消化系统]