合并抑郁的哮喘患儿血清IL-17、COR水平及其意义  

The levels and significance of IL-17 and COR in asthmatic children with depression

作　　者：杜鑫 易贤红 李建木[1] 杨凡[1] 冯玲玲[1] DU Xin;YI Xianhong;LI Jianmu(Department of Pediatrics,the First People's Hospital of Xiantao City,Xiantao 433099,China)

机构地区：[1]仙桃市第一人民医院儿科,仙桃433099

出　　处：《国际精神病学杂志》2024年第5期1493-1495,1519,共4页Journal Of International Psychiatry

摘　　要：目的 探讨哮喘合并抑郁患儿血清白细胞介素-17(IL-17)、皮质醇(COR)的水平及其意义。方法 回顾性分析2020年1月~2022年2月来本院就诊的87例哮喘患儿病历资料,根据是否发生抑郁将其分为抑郁组(n=41)和未抑郁组(n=46),对比两组血清中IL-17、COR水平;根据抑郁量表不同得分将哮喘合并抑郁患儿分为轻度抑郁组(n=22)、中度抑郁组(n=9)和重度抑郁组(n=10),对比三组患儿血清中IL-17、COR水平,采用受试者工作曲线(ROC)分析IL-17、COR水平对哮喘合并抑郁的诊断价值。结果 87例哮喘患儿中有41例发生抑郁,46例未抑郁,哮喘合并抑郁发生率为47.13%;抑郁组患儿血清中IL-17、COR水平均高于未抑郁组(P<0.05);轻度抑郁组IL-17、COR水平均低于中度抑郁组(P<0.05)和重度抑郁组(P<0.05);中度抑郁组IL-17、COR水平均低于重度抑郁组(P<0.05);ROC曲线分析显示,IL-17、COR联合检测哮喘合并抑郁的曲线下面积(AUC)为0.922,高于L-17和COR单独预测(0.871、0.812)。结论 哮喘合并抑郁患儿血清IL-17、COR水平高于单纯哮喘患儿,且随着病情的进展,IL-17、COR水平逐渐升高,二者对哮喘合并抑郁的诊断均有一定的价值,联合检测可提高诊断效能。Objective To investigate the significance of interleukin-17(IL-17)and cortisol(COR)levels in asthmatic children with depression.Methods The medical records of 87 children with asthma from January 2020 to February 2022 were analyzed retrospectively.According to whether they had depression,they were divided into depression group(n=41)and non-depression group(n=46).Serum IL-17 and COR levels were compared between the two groups.According to the different scores of depression scale,the children with asthma and depression were divided into mild depression group(n=22),moderate depression group(n=9)and severe depression group(n=10).The levels of IL-17and COR in serum of the three groups were compared.Receiver operating curve(ROC)was used to analyze the diagnostic value of IL-17 and COR in asthma with depression.Results Among 87 children with asthma,41 had depression and 46had no depression.The incidence of asthma with depression was 47.13%.The serum levels of IL-17 and COR in depression group were higher than those in non-depression group(P<0.05).The levels of IL-17 and COR in mild depression group were lower than those in moderate depression group(P<0.05)and severe depression group(P<0.05).The levels of IL-17 and COR in moderate depression group were lower than those in severe depression group(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of the combination of IL-17 and COR was 0.922,which was higher than that of L-17 and COR alone(0.871,0.812).Conclusion The serum levels of IL-17 and COR in children with asthma complicated with depression are higher than those in children with asthma alone,and the levels of IL-17 and COR increase gradually with the progress of the disease.Both of them have certain value in the diagnosis of asthma complicated with depression,and the combined detection can improve the diagnostic efficiency.

关 键 词：哮喘 抑郁 白细胞介素-17 皮质醇 诊断价值 

分 类 号：R749.4[医药卫生—神经病学与精神病学]