An olsalazine nanoneedle-embedded inulin hydrogel reshapes intestinal homeostasis in inflammatory bowel disease  

作　　者：Zhuangzhuang Zhang Yang Pan Zhaoyuan Guo Xi Fan Qingqing Pan Wenxia Gao Kui Luo Yuji Pu Bin He 

机构地区：[1]National Engineering Research Center for Biomaterials,College of Biomedical Engineering,Sichuan University,Chengdu,610064,China [2]School of Preclinical Medicine,Chengdu University,Chengdu,610106,China [3]College of Chemistry&Materials Engineering,Wenzhou University,Wenzhou,325027,China [4]Huaxi MR Research Center(HMRRC),Department of Radiology,West China Hospital,Functional and Molecular Imaging Key Laboratory of Sichuan Province,Sichuan University,China

出　　处：《Bioactive Materials》2024年第3期71-84,共14页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(51903172,52073216);the Sichuan Science and Technology Program(2022NSFSC1939).

摘　　要：Inflammatory bowel disease(IBD)is a chronic and refractory condition characterized by disrupted epithelial barrier,dysregulated immune balance,and altered gut microbiota.Nano-enabled interventions for restoring gut homeostasis have the potential to alleviate inflammation in IBD.Herein,we developed a combination of olsalazine(Olsa)-based nanoneedles and microbiota-regulating inulin gel to reshape intestinal homeostasis and relieve inflammation.The Olsa-derived nanoneedles exhibited reactive oxygen species scavenging ability and anti-inflammatory effects in lipopolysaccharide-simulated macrophages.The composite of nanoneedles and inulin gel(Cu2(Olsa)/Gel)displayed a macroporous structure,improved bio-adhesion,and enhanced colon retention after oral administration.Mechanistically,the composite effectively downregulated pro-inflammatory cytokine levels and promoted epithelial barrier repair through anti-inflammatory and antioxidant therapies,resulting in significant alleviation of colitis in three animal models of IBD.Furthermore,analysis of gut microbiota revealed that Cu2(Olsa)/Gel treatment increased the diversity of intestinal microflora and decreased the relative abundance of pathogenic bacteria such as Proteobacteria.Overall,this study provides a self-delivering nanodrug and dietary fiber hydrogel composite for IBD therapy,offering an efficient approach to restore intestinal homeostasis.

关 键 词：Inflammatory bowel disease Intestinal homeostasis Olsalazine Hydrogel NANONEEDLE 

分 类 号：R574[医药卫生—消化系统]