NIR-II light triggered burst-release cascade nanoreactor for precise cancer chemotherapy  

作　　者：Yu-Jing Pan Yang Zhang Biao-Qi Chen Yi Zhao Jin-Yang Wang Chang-Yong Li Da-Gui Zhang Ranjith Kumar Kankala Shi-Bin Wang Gang Liu Ai-Zheng Chen 

机构地区：[1]Fujian Provincial Key Laboratory of Biochemical Technology&Institute of Biomaterials and Tissue Engineering,Huaqiao University,Xiamen,361021,China [2]Center for Nanomedicine and Department of Anesthesiology,Perioperative and Pain Medicine,Brigham and Women’s Hospital,Harvard Medical School,Boston,MA,02115,USA [3]State Key Laboratory of Vaccines for Infectious Diseases,Xiang An Biomedicine Laboratory,National Innovation Platform for Industry-Education Integration in Vaccine Research,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen,361102,China

出　　处：《Bioactive Materials》2024年第3期311-323,共13页生物活性材料（英文）

基　　金：support from the National Natural Science Foundation of China(NSFC,81971734,32071323,32271410,and 82202330);the National Key Research&Development Program of China(2019YFE0113600);the Science and Technology Projects in Fujian Province(2022FX1,2023Y4008);the Program for Innovative Research Team in Science and Technology in Fujian Province University,and the Scientific Research Funds of Huaqiao University(23BS113).

摘　　要：The current strategy of co-delivering copper ions and disulfiram(DSF)to generate cytotoxic CuET faces limitations in achieving rapid and substantial CuET production,specifically in tumor lesions.To overcome this challenge,we introduce a novel burst-release cascade reactor composed of phase change materials(PCMs)encapsulating ultrasmall Cu_(2-x)Se nanoparticles(NPs)and DSF(DSF/Cu_(2-x)Se@PCM).Once triggered by second near-infrared(NIR-II)light irradiation,the reactor swiftly releases Cu_(2-x)Se NPs and DSF,enabling catalytic reactions that lead to the rapid and massive production of Cu_(2-x)Se-ET complexes,thereby achieving in situ chemotherapy.The mechanism of the burst reaction is due to the unique properties of ultrasmall Cu_(2-x)Se NPs,including their small size,multiple defects,and high surface activity.These characteristics allow DSF to be directly reduced and chelated on the surface defect sites of Cu_(2-x)Se,forming Cu_(2-x)Se-ET complexes without the need for copper ion release.Additionally,Cu_(2-x)Se-ET has demonstrated a similar(to CuET)anti-tumor activity through increased autophagy,but with even greater potency due to its unique two-dimensional-like structure.The light-triggered cascade of interlocking reactions,coupled with in situ explosive generation of tumor-suppressive substances mediated by the size and valence of Cu_(2-x)Se,presents a promising approach for the development of innovative nanoplatforms in the field of precise tumor chemotherapy.

关 键 词：Ultrasmall Cu_(2-x)Se nanoparticles High surface activity NANOREACTOR Phase change materials Precise chemotherapy 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R730.53[医药卫生—肿瘤]