Cell-homing and immunomodulatory composite hydrogels for effective wound healing with neovascularization  

作　　者：Hayeon Byun Yujin Han Eunhyung Kim Indong Jun Jinkyu Lee Hyewoo Jeong Seung Jae Huh Jinmyoung Joo Su Ryon Shin Heungsoo Shin 

机构地区：[1]Department of Bioengineering,Hanyang University,222 Wangsimni-ro,Seongdong-gu,Seoul 04763,Republic of Korea [2]Division of Engineering in Medicine,Department of Medicine,Harvard Medical School,Brigham and Women’s Hospital,Cambridge,MA 02139,USA [3]Environmental Safety Group,Korea Institute of Science&Technology Europe(KIST-EUROPE),Saarbrücken 66123,Germany [4]Department of Biomedical Engineering,Ulsan National Institute of Science and Technology(UNIST),Ulsan 44919,Republic of Korea [5]Institute of Nano Science and Technology,Hanyang University,222 Wangsimni-ro,Seongdong-gu,Seoul 04763,Republic of Korea

出　　处：《Bioactive Materials》2024年第6期185-202,共18页生物活性材料（英文）

基　　金：supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.RS-2023-00207746,RS-2023-00207983);a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI);funded by the Ministry of Health&Welfare,Republic of Korea(grant number:HI19C075300).

摘　　要：Wound healing in cases of excessive inflammation poses a significant challenge due to compromised neovascularization.Here,we propose a multi-functional composite hydrogel engineered to overcome such conditions through recruitment and activation of macrophages with adapted degradation of the hydrogel.The composite hydrogel(G-TSrP)is created by combining gelatin methacryloyl(GelMA)and nanoparticles(TSrP)composed of tannic acid(TA)and Sr^(2+).These nanoparticles are prepared using a one-step mineralization process assisted by metal-phenolic network formation.G-TSrP exhibits the ability to eliminate reactive oxygen species and direct polarization of macrophages toward M2 phenotype.It has been observed that the liberation of TA and Sr^(2+)from G-TSrP actively facilitate the recruitment and up-regulation of the expression of extracellular matrix remodeling genes of macrophages,and thereby,coordinate in vivo adapted degradation of the G-TSrP.Most significantly,G-TSrP accelerates angiogenesis despite the TA’s inhibitory properties,which are counteracted by the released Sr^(2+).Moreover,G-TSrP enhances wound closure under inflammation and promotes normal tissue formation with strong vessel growth.Genetic analysis confirms macrophage-mediated wound healing by the composite hydrogel.Collectively,these findings pave the way for the development of biomaterials that promote wound healing by creating regenerative environment.

关 键 词：IMMUNOMODULATION Wound healing NEOVASCULARIZATION Multi-functional nanoparticles Composite hydrogels 

分 类 号：R318[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]