Nanomaterials modulate tumor-associated macrophages for the treatment of digestive system tumors  

作　　者：Hao Li Shuai Wang Zhengqiang Yang Xianwei Meng Meng Niu 

机构地区：[1]Department of Interventional Radiology,First Hospital of China Medical University,Shenyang,China [2]Department of Interventional Therapy,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China [3]Laboratory of Controllable Preparation and Application of Nanomaterials,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing,China [4]China Medical University,Shenyang,China

出　　处：《Bioactive Materials》2024年第6期376-412,共37页生物活性材料（英文）

基　　金：supported by National Natural Science Foundation of China,62371474(MN);Natural Science Foundation of Liaoning Province,2023JH2/101600006(MN).

摘　　要：The treatment of digestive system tumors presents challenges,particularly in immunotherapy,owing to the advanced immune tolerance of the digestive system.Nanomaterials have emerged as a promising approach for addressing these challenges.They provide targeted drug delivery,enhanced permeability,high bioavailability,and low toxicity.Additionally,nanomaterials target immunosuppressive cells and reshape the tumor immune microenvironment(TIME).Among the various cells in the TIME,tumor-associated macrophages(TAMs)are the most abundant and play a crucial role in tumor progression.Therefore,investigating the modulation of TAMs by nanomaterials for the treatment of digestive system tumors is of great significance.Here,we present a comprehensive review of the utilization of nanomaterials to modulate TAMs for the treatment of gastric cancer,colorectal cancer,hepatocellular carcinoma,and pancreatic cancer.We also investigated the underlying mechanisms by which nanomaterials modulate TAMs to treat tumors in the digestive system.Furthermore,this review summarizes the role of macrophage-derived nanomaterials in the treatment of digestive system tumors.Overall,this research offers valuable insights into the development of nanomaterials tailored for the treatment of digestive system tumors.

关 键 词：Digestive system tumors Tumor-associated macrophages NANOMATERIALS Tumor immune microenvironment THERAPY 

分 类 号：R735[医药卫生—肿瘤]