In situ sustained release hydrogel system delivering GLUT1 inhibitor and chemo-drug for cancer post-surgical treatment  

作　　者：Lanqing Wang Zi Mei Guanyu Jin Hao Liu Shixian Lv Runjia Fu Muxing Li Cuiping Yao 

机构地区：[1]Institute of Biomedical Photonics and Sensing,School of Life Science and Technology,Key Laboratory of Biomedical Information Engineering of Ministry of Education,Xi’an Jiaotong University,Xi’an,710049,China [2]School of Stomatology,School of Materials Science and Engineering,Department of General Surgery,Third Hospital,Peking University,Beijing,100871,China [3]Department of Oncology,The Second Hospital,Cheeloo College of Medicine,Shandong University,Jinan,250033,China

出　　处：《Bioactive Materials》2024年第6期541-550,共10页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(62175198,52273114,82103323,82003992,and U22A2092);the Fundamental Research Funds for the Central Universities(xtr062022002);Key Research and Development Program of Shaanxi Province under Grant No.2022ZDLSF04-09;Beijing Natural Science Foundation(7222214).

摘　　要：Systematic administration of small molecular drugs often suffered from the low efficacy and systemic toxicity in cancer therapy.In addition,application of single mode drug usually leads to unsatisfactory therapeutic out-comes.Currently,developing multimodal-drug combination strategy that acts on different pathways without increasing side effects remains great challenge.Here,we developed a hydrogel system that co-delivered glycolysis inhibitor apigenin and chemo-drug gemcitabine to realize combination strategy for combating can-cer with minimal systemic toxicity.We demonstrated that this system can not only eliminate tumor cells in situ,but also induce abscopal effect on various tumor models.These results showed that our study provided a safe and effective strategy for clinical cancer treatment.

关 键 词：Chitosan-based hydrogel Drug delivery CONTROLLED-RELEASE Abscopal effect Polymer carriers 

分 类 号：TQ427.26[化学工程] R73[医药卫生—肿瘤]