Tuning zinc content in wollastonite bioceramic endowing outstanding angiogenic and antibacterial functions beneficial for orbital reconstruction  

作　　者：Yiyu Peng Menglu Chen Jingyi Wang Jiajun Xie Changjun Wang Xianyan Yang Xiaoling Huang Zhongru Gou Juan Ye 

机构地区：[1]Eye Center,The Second Affiliated Hospital,Zhejiang University School of Medicine,Zhejiang,Provincial Key Lab of Ophthalmology,Hangzhou,310009,China [2]Bio-nanomaterials and Regenerative Medicine Research Division,Zhejiang-California International Nanosystem Institute,Zhejiang University,Hangzhou,310058,China

出　　处：《Bioactive Materials》2024年第6期551-564,共14页生物活性材料（英文）

基　　金：the National Natural Science Foundation Regional Innovation and Development Joint Fund(U20A20386);the Zhejiang Provincial Basic Research for Public Welfare Funds(LGF22E030002);National Natural Science Foundation of China(82330032,82201236);Zhejiang Provincial Natural Science Foundation of China(LZ22E020002).

摘　　要：Prosthetic eye is indispensable as filler after enucleation in patients with anophthalmia,whereas there are still many complications including postoperative infection and eye socket depression or extrusion during the conventional artificial eye material applications.Some Ca-silicate biomaterials showed superior bioactivity but their biological stability in vivo limit the biomedical application as long-term or permanent implants.Herein we aimed to understand the physicochemical and potential biological responses of zinc doping in wollastonite bioceramic used for orbital implants.The wollastonite powders with different zinc dopant contents(CSi-Znx)could be fabricated as porous implants with strut or curve surface pore geometries(cubic,IWP)via ceramic stereolithography.The experimental results indicated that,by increasing zinc-substituting-Ca ratio(up to 9%),the sintering and mechanical properties could be significantly enhanced,and meanwhile the bio-dissolution in vitro and biodegradability in vivo were thoroughly inhibited.In particular,an appreciable angiogenic activity and expected antibacterial efficacy(over 90%)were synergistically achieved at 9 mol%Zn dopant.In the back-embedding and enucleation and implantation model experiments in rabbits,the superior continuous angiogenesis was corroborated from the 2D/3D fibrovascular reconstruction in the IWP-pore CSi-Zn9 and CSi-Zn13.5 groups within very short time stages.Totally,the present silicate-based bioceramic via selective Zn doping could produce outstanding structural stability and bifunctional biological responses which is especially valuable for developing the next-generation implants with vascular insertion and fixation in orbital reconstruction prothesis.

关 键 词：Zinc doping ANTIBACTERIAL ANGIOGENESIS Wollastonite bioceramic Orbital reconstruction 

分 类 号：R318[医药卫生—生物医学工程]