Bioinspired multifunctional cellulose film:In situ bacterial capturing and killing for managing infected wounds  

作　　者：Chengcheng Li Ya-Xuan Zhu Ying Yang Wanting Miao Xiaotong Shi Ke-Fei Xu Zi-Heng Li Huining Xiao Fu-Gen Wu 

机构地区：[1]International Innovation Center for Forest Chemicals and Materials and Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources,Nanjing Forestry University,Nanjing,210037,China [2]State Key Laboratory of Digital Medical Engineering,Jiangsu Key Laboratory for Biomaterials and Devices,School of Biological Science and Medical Engineering,Southeast University,2 Southeast University Road,Nanjing,211189,China [3]Department of Chemical Engineering,University of New Brunswick,Fredericton,New Brunswick,E3B 5A3,Canada [4]Shanghai Frontiers Science Center of Nanocatalytic Medicine,Shanghai Tenth People’s Hospital,School of Medicine,Tongji University,Shanghai,200092,China

出　　处：《Bioactive Materials》2024年第6期595-612,共18页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(32101916 and 22205166);the Natural Science Foundation of Jiangsu Province(BK20200619).

摘　　要：Bacterial infection of cutaneous wounds can easily lead to occurrence of chronic wounds and even more serious diseases.Therefore,multifunctional,biodegradable,and reusable wound dressings that can quickly manage wound infection and promote wound healing are urgently desired.Herein,inspired by the“capturing and killing”action of Drosera peltata Thunb.,a biomimetic cellulose film was constructed to capture the bacteria(via the rough structure of the film)and kill them(via the combination of photodynamic therapy and chemotherapy)to promote wound tissue remodeling.The film(termed OBC-PR)was simply prepared by chemically crosslinking the oxidized bacterial cellulose(OBC)with polyhexamethylene guanidine hydrochloride(PHGH)and rose bengal(RB).Notably,it could effectively capture Escherichia coli and Staphylococcus aureus bacterial cells with capture efficiencies of~99%and~96%,respectively,within 10 min.Furthermore,the in vivo experiments showed that OBC-PR could effectively promote the macrophage polarization toward the M2 phenotype and adequately induce the reconstruction of blood vessels and nerves,thus promoting wound healing.This study provides a potential direction for designing multifunctional wound dressings for managing infected skin wounds in the future.

关 键 词：Bacterial cellulose ANTIBACTERIAL ANTIINFLAMMATION ANGIOGENESIS Wound healing 

分 类 号：R318[医药卫生—生物医学工程]