A bioactive composite hydrogel dressing that promotes healing of both acute and chronic diabetic skin wounds  

作　　者：Shunlai Shang Kaiting Zhuang Jianwen Chen Ming Zhang Shimin Jiang Wenge Li 

机构地区：[1]Department of Nephrology,China-Japan Friendship Hospital,Beijing,China [2]Department of Nephrology,First Medical Center of Chinese PLA General Hospital,Nephrology Institute of the Chinese People’s Liberation Army,National Key Laboratory of Kidney Diseases,National Clinical Research Center for Kidney Diseases,Beijing Key Laboratory of Kidney Disease Research,Beijing,100853,China [3]Department of Nephrology,Affiliated Beijing Chaoyang Hospital of Capital Medical University,Beijing,100020,China

出　　处：《Bioactive Materials》2024年第4期298-310,共13页生物活性材料（英文）

基　　金：supported by National High Level Hospital Clinical Research Funding,(2023-NHLHCRF-YS-01);Elite Medical Professionals Project of China-Japan Friendship Hospital(ZRJY2023-GG06);the China Postdoctoral Science Foundation(Certificate Number:2023M733986 and 2023T160741);Cross-sectional project of China-Japan Friendship Hospital(Certificate Number:2023-HX-JC-10);International Association of Chinese Nephrologists Research Grant(No.IACNRG-01);Beijing Hospitals Authority Clinical medicine Development of special funding support(Certificate Number:ZLRK202308).

摘　　要：Mesenchymal stem cell derived exosomes(MSC-Exos)demonstrate beneficial effects on wound healing via anti-inflammatory and angiogenic properties.Chitosan(CS)exhibits excellent biocompatibility and accelerates cellular migration,adhesion,and proliferation.The ions released from bioactive glass(BG)and titanium dioxide(TiO_(2))nanoparticles exhibit sustained angiogenic and antibacterial potency.In this study,CMCS-CEBT hydrogel was synthesized from exosomes encapsulated carboxymethyl chitosan(CMCS),chitosan nanoparticles(CS-NPs),BG,and TiO_(2)nanoparticles for a preliminary evaluation of its impacts on the treatment of full-thickness skin defects,diabetic wounds,and burn skin injury due to burns.In vitro analysis indicated that the hydrogel exhibits excellent cell compatibility,stimulates endothelial cell adhesion and proliferation,and presents anti-inflammatory,angiogenic,and antibacterial activities.In vivo,the composite hydrogel dressing accelerated a wound healing acceleration effect,stimulated angiogenesis,and increased collagen deposition and the expression of anti-inflammatory factors.This innovative composite hydrogel dressing as a potential clinical therapy,utilizing bioactive materials,holds promise as a potential clinical therapy that aims to facilitate the regeneration of acute and chronically damaged skin tissue.

关 键 词：EXOSOMES Bioactive glass Diabetic wound ANTI-INFLAMMATORY Titanium dioxide 

分 类 号：R318.08[医药卫生—生物医学工程]