Piezo-enhanced near infrared photocatalytic nanoheterojunction integrated injectable biopolymer hydrogel for anti-osteosarcoma and osteogenesis combination therapy  

作　　者：Cairong Xiao Renxian Wang Rumin Fu Peng Yu Jianxun Guo Guangping Li Zhengao Wang Honggang Wang Jingjun Nie Weifeng Liu Jinxia Zhai Changhao Li Chunlin Deng Dafu Chen Lei Zhou Chengyun Ning 

机构地区：[1]School of Materials Science and Engineering,National Engineering Research Center for Tissue Restoration and Reconstruction,South China University of Technology,Guangzhou,510641,China [2]Laboratory of Bone Tissue Engineering,Beijing Laboratory of Biomedical Materials,National Center for Orthopaedics,Beijing Research Institute of Traumatology and Orthopaedics,Beijing Jishuitan Hospital,Beijing,100035,China [3]JST Sarcopenia Research Centre,Beijing Research Institute of Traumatology and Orthopaedics,Beijing Jishuitan Hospital,Beijing,100035,China [4]Department of Orthopaedic Oncology Surgery,Beijing Jishuitan Hospital,Peking University,Beijing,100035,China [5]Hospital of Stomatology,Guanghua School of Stomatology,Sun Yat-sen University and Guangdong Key Laboratory of Stomatology,Guangzhou,Guangdong,510055,China [6]Guangzhou Key Laboratory of Spine Disease Prevention and Treatment,Department of Spine Surgery,The Third Affiliated Hospital,Guangzhou Medical University,Guangzhou,510150,China

出　　处：《Bioactive Materials》2024年第4期381-400,共20页生物活性材料（英文）

基　　金：supported by the National Key R&D Program of China(Nos.2021YFC2400402 and 2021YFC2400405);the National Natural Science Foundation of China(Nos.52072127,52173275,52201297,51932002);Beijing Municipal Health Commission(BJRITO-RDP-2023,PXM 2020_026275_000002 and BMHC-2021-6);the Natural Science Foundation of Guangdong Province(2021A0505030083 and 202201010228);the Guangdong Basic and Applied Basic Research Foundation(2023A1515010784);the China Postdoctoral Science Foundation(No.2023M743979).

摘　　要：Preventing local tumor recurrence while promoting bone tissue regeneration is an urgent need for osteosarcoma treatment.However,the therapeutic efficacy of traditional photosensitizers is limited,and they lack the ability to regenerate bone.Here,a piezo-photo nanoheterostructure is developed based on ultrasmall bismuth/strontium titanate nanocubes(denoted as Bi/SrTiO_(3)),which achieve piezoelectric field-driven fast charge separation coupling with surface plasmon resonance to efficiently generate reactive oxygen species.These hybrid nanotherapeutics are integrated into injectable biopolymer hydrogels,which exhibit outstanding anticancer effects under the combined irradiation of NIR and ultrasound.In vivo studies using patient-derived xenograft models and tibial osteosarcoma models demonstrate that the hydrogels achieve tumor suppression with efficacy rates of 98.6%and 67.6%in the respective models.Furthermore,the hydrogel had good filling and retention capabilities in the bone defect region,which exerted bone repair therapeutic efficacy by polarizing and conveying electrical stimuli to the cells under mild ultrasound radiation.This study provides a comprehensive and clinically feasible strategy for the overall treatment and tissue regeneration of osteosarcoma.

关 键 词：Surface plasmon resonance Piezo-enhanced photodynamic Piezoelectric stimulation Anti-osteosarcoma OSTEOGENESIS 

分 类 号：TQ427.26[化学工程] R318[医药卫生—生物医学工程]