模式生物果蝇在中医药现代研究中的优势与应用前景  

Advantages and application prospects of model organism Drosophila in modern research of traditional Chinese medicine

作　　者：何丽 张永宣 李泊潼 秦玉洁 吴依凡 刘永琦[3] 修明慧 和建政 HE Li;ZHANG Yong-xuan;LI Bo-tong;QIN Yu-jie;WU Yi-fan;LIU Yong-qi;XIU Ming-hui;HE Jian-zheng(School of Public Health,Gansu University of Chinese Medicine,Lanzhou 730000,China;School of Basic Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Key Laboratory of Dunhuang Medicine and Transformation,Ministry of Education,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学公共卫生学院,甘肃兰州730000 [2]甘肃中医药大学基础医学院,甘肃兰州730000 [3]敦煌医学与转化教育部重点实验室,甘肃兰州730000

出　　处：《中国中药杂志》2024年第20期5410-5421,共12页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(82360896);甘肃省自然科学基金项目(23JRRA1202);兰州市科技计划项目(2023-4-53)。

摘　　要：中医药具有多种活性成分,生物活性多样,不良反应小且不易耐药,被广泛应用于防治各种疾病。经典模式生物黑腹果蝇以其生命周期短、生理结构简单、培养成本低及操作简便等优势,借助转基因和基因定点敲除等基因调控技术在中医药现代研究中得到了广泛应用。该文以炎症性肠病、衰老、肿瘤、神经退行性疾病、睡眠障碍等疾病为例概述果蝇在中医药现代研究中的进展,以期为模式生物果蝇在中医药领域的研究应用提供新的方法和技术。Traditional Chinese medicine(TCM)is widely used to prevent and treat various diseases due to its many active ingre-dients,diverse biological activities,low side effects,and drug resistance.The classical model organism Drosophila melanogaster,with its advantages of short life cycle,simple physiological structure,low cultivation cost,and easy operation,has been widely used in the modern research of TCM through gene regulation techniques including transgenic and gene knockout techniques.In this paper,the ap-plication of Drosophila in modern research of TCM was outlined from the disease models of inflammatory bowel disease,aging,tumor,neurodegenerative disease,and sleep disorders,with a view to providing new methods and techniques for the research and application of the model organism Drosophila in the field of TCM.

关 键 词：黑腹果蝇 中医药现代研究 炎症性肠病 衰老 肿瘤 神经退行性疾病 睡眠障碍 

分 类 号：R-332[医药卫生]