Wireless closed-loop deep brain stimulation using microelectrode array probes  

作　　者：Qianli JIA Yaoyao LIU Shiya LV Yiding WANG Peiyao JIAO Wei XU Zhaojie XU Mixia WANG Xinxia CAI 

机构地区：[1]State Key Laboratory of Transducer Technology,Aerospace Information Research Institute,Chinese Academy of Sciences,Beijing 100190,China [2]School of Electronic,Electrical and Communication Engineering,University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第10期803-823,共21页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the National Natural Science Foundation of China(Nos.T2293730,T2293731,62121003,61960206012,61973292,62171434,61975206,and 61971400);the National Key Research and Development Program of China(Nos.2022YFC2402501 and 2022YFB3205602);the Major Program of Scientific and Technical Innovation 2030(No.2021ZD02016030);the Scientific Instrument Developing Project of the Chinese Academy of Sciences(No.GJJSTD20210004).

摘　　要：Deep brain stimulation(DBS),including optical stimulation and electrical stimulation,has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural disorders.Advances in DBS microsystems based on implantable microelectrode array(MEA)probes have opened up new opportunities for closed-loop DBS(CL-DBS)in situ.This technology can be used to detect damaged brain circuits and test the therapeutic potential for modulating the output of these circuits in a variety of diseases simultaneously.Despite the success and rapid utilization of MEA probe-based CL-DBS microsystems,key challenges,including excessive wired communication,need to be urgently resolved.In this review,we considered recent advances in MEA probe-based wireless CL-DBS microsystems and outlined the major issues and promising prospects in this field.This technology has the potential to offer novel therapeutic options for psychiatric disorders in the future.

关 键 词：Deep brain stimulation(DBS) Wireless closed-loop deep brain stimulation(CL-DBS)microsystem Microelectrode array(MEA)probe Optical stimulation Electrical stimulation 

分 类 号：R74[医药卫生—神经病学与精神病学] R318[医药卫生—临床医学]