Phenolic-enabled nanotechnology:a new strategy for central nervous system disease therapy  

作　　者：Yuyi ZHENG Xiaojie CHEN Yi WANG Zhong CHEN Di WU 

机构地区：[1]Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province,School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China [2]Zhejiang Rehabilitation Medical Center,the Third Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310009,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第10期890-913,共24页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the National Natural Science Foundation of China(No.82273861);the Young Elite Scientists Sponsorship Program by China Association for Science and Technology(CAST)(No.YESS20220139).

摘　　要：Polyphenolic compounds have received tremendous attention in biomedicine because of their good biocompatibility and unique physicochemical properties.In recent years,phenolic-enabled nanotechnology(PEN)has become a hotspot of research in the medical field,and many promising studies have been reported,especially in the application of central nervous system(CNS)diseases.Polyphenolic compounds have superior anti-inflammatory and antioxidant properties,and can easily cross the blood‒brain barrier,as well as protect the nervous system from metabolic damage and promote learning and cognitive functions.However,although great advances have been made in this field,a comprehensive review regarding PEN-based nanomaterials for CNS therapy is lacking.A systematic summary of the basic mechanisms and synthetic strategies of PEN-based nanomaterials is beneficial for meeting the demand for the further development of novel treatments for CNS diseases.This review systematically introduces the fundamental physicochemical properties of PEN-based nanomaterials and their applications in the treatment of CNS diseases.We first describe the different ways in which polyphenols interact with other substances to form high-quality products with controlled sizes,shapes,compositions,and surface chemistry and functions.The application of PEN-based nanomaterials in the treatment of CNS diseases is then described,which provides a reference for subsequent research on the treatment of CNS diseases.

关 键 词：Phenolic-enabled nanotechnology(PEN) Metal-phenolic network POLYDOPAMINE Central nervous system(CNS) Drug delivery system 

分 类 号：R74[医药卫生—神经病学与精神病学] R318[医药卫生—临床医学]