新生儿出生体重与脐动/静脉血清中矿物质水平的关系  

Relationship between birth weight and mineral levels in umbilical artery and vein serum

作　　者：邢新新 金子程 王烨 刘小兵 戴楠[3] 赖建强 Xing Xinxin;Jin Zicheng;Wang Ye;Liu Xiaobing;Dai Nan;Lai Jianqiang(National Institute for Nutrition and Health,Chinese Center for Disease Control and Prevention,Beijingg100050,China;Qingdao Center for Disease Control and Prevention,Qingdao 266033,China;Danyang People Hospital of Jiangsu Province,Zhenjiang 212300,China)

机构地区：[1]中国疾病预防控制中心营养与健康所,北京100050 [2]青岛市疾病预防控制中心,青岛266033 [3]江苏省丹阳市人民医院,镇江212300

出　　处：《卫生研究》2024年第6期961-966,1006,共7页Journal of Hygiene Research

基　　金：国家重点研发计划(No.2017YFD0400600)。

摘　　要：目的通过测量脐静脉和脐动脉血清中矿物质水平,比较脐静脉血和脐动脉血中矿物质水平的差异,分析脐动/静脉血清中矿物质水平与新生儿出生体重的关系。方法采用横断面研究方法,选取2021年6-9月在江苏省丹阳市人民医院住院分娩的101对母婴作为研究对象,娩出胎儿后,采集新生儿脐静脉血和脐动脉血,使用电感耦合等离子体质谱(ICP-MS)技术检测脐动脉和脐静脉血清中锰(Mn)、铁(Fe)、钴(Co)、铜(Cu)、锌(Zn)、硒(Se)、镁(Mg)、钙(Ca)水平。配对比较脐动脉和脐静脉血清矿物质水平,采用Logistic回归分析探索新生儿出生体重与脐动/静脉血清中矿物质水平的关系。结果脐静脉血清中Se、Mg、Ca的水平高于脐动脉,而Mn和Fe的水平低于脐动脉(P<0.05)。在校正血清白蛋白后,脐静脉血清中Ca水平显著高于脐动脉血,而Mn、Fe和Zn的水平低于脐动脉(P<0.05)。不同出生体重组间比较,小于胎龄儿(small for gestational age,SGA)组脐静脉血清中Zn、Ca水平低于适于胎龄儿(appropriate for gestational age,AGA)和大于胎龄儿(large for gestational age,LGA)组,脐动脉血清中Cu水平在LGA组最高(P=0.059)。多因素分析结果显示,与AGA相比,脐动脉血清中高水平的Mn与LGA发生相关(OR=0.15,P=0.040),其它矿物质与出生体重无统计学关联。结论脐静脉和脐动脉血中矿物质水平存在差异,且与新生儿出生体重相关。OBJECTIVEE To compare the mineral levels in umbilical vein and artery serum and to analyze the relationship between newborn birth weight and the mineral levels in umbilical vein and artery serum by measuring the mineral levels in umbilical vein and artery serum.METHODS A cross-sectional study was conducted to recruit 101 pairs of maternal and newborn who were hospitalized in Danyang People's Hospital,Jiangsu Province from June to September 2021 as the participants.After delivery,umbilical vein and artery blood were collected,and the levels of manganese(Mn),iron(Fe),cobalt(Co),copper(Cu),zinc(Zn),selenium(Se),magnesium(Mg)and calcium(Ca)in umbilical vein and artery serum were detected by inductively coupled plasma mass spectrum(ICP-MS).The serum mineral levels of umbilical artery and vein were compared by matching method,and logistic regression analysis was used to explore the relationship between birth weight and mineral levels in umbilical artery and vein serum.RESULTS The levels of Se,Mg and Ca in umbilical vein were higher than those in umbilical artery,but the levels of Mn and Fe were lower(P<0.05).After adjusting serum albumin,the level of Ca in umbilical vein was higher than that in umbilical artery and the levels of Mn,Fe and Zn were lower(P<0.05).Compared among different birth weight groups,the levels of Zn and Ca in umbilical vein serum in the small for gestational age(SGA)group were lower than those in the appropriate for gestational age(AGA)group and the larger for gestational age(LGA)group(P<0.05),and the level of Cu in umbilical artery serum was higher in the LGA group(P=0.059).The result of multivariate analysis showed that compared with the AGA group,high levels of Mn in umbilical artery serum were negatively correlated with LGA(OR=0.15,P=0.040),while other minerals were not statistically correlated with birth weight.CONCLUSION There are differences in mineral content between umbilical vein and umbilical artery.Mineral levels in umbilical arterial/venous serum were correlated with birth weight.

关 键 词：出生体重 矿物质 脐带血 横断面研究 

分 类 号：R151[医药卫生—营养与食品卫生学] R153[医药卫生—公共卫生与预防医学]