阿昔替尼靶向治疗致可逆性后部脑白质病综合征1例  

A case of reversible posterior leukoencephalopathy syndrome induced by axitinib targeted therapy

作　　者：刘梅 何立香[1] 李建旺[1] 吕蔡[2] 陈琳[3] 孟娟[1] Liu Mei;He Lixiang;Li Jianwang;LüCai;Chen Lin;Meng Juan(Department of Oncology,Haikou People's Hospital,Haikou 570208,China;Department of Urology,Haikou People's Hospital,Haikou 570208,China;Department of Pharmacy,Haikou People's Hospital,Haikou 570208,China)

机构地区：[1]海口市人民医院肿瘤内科,海南海口570208 [2]海口市人民医院泌尿外科,海南海口570208 [3]海口市人民医院药学部,海南海口570208

出　　处：《实用药物与临床》2024年第11期862-865,共4页Practical Pharmacy and Clinical Remedies

摘　　要：1例67岁女性肾透明细胞癌患者口服阿昔替尼5 mg bid,服药24 d后,患者因头晕伴恶心、呕吐收入我院,后逐渐出现头痛、视力障碍和血压升高,颅脑MRI提示双侧额顶枕叶、左侧颞叶白质区异常信号,诊断为可逆性后部脑白质病综合征(Reversible posterior leukoencephalopathy syndrome,RPLS),经停服阿昔替尼及对症处理,1周后患者症状及影像病变完全消失。本文分析1例应用阿昔替尼导致可逆性后部脑白质病综合征的不良反应病例,以期引起临床重视。A 67-year-old female patient with renal clear cell carcinoma was treated with oral axitinib 5 mg bid.After 24 days of medication,the patient was admitted to our hospital due to dizziness accompanied by nausea and vomiting,followed by gradual emergence of headache,visual impairment,and increased blood pressure.Brain MRI revealed abnormal signals in the bilateral frontal,parietal,and occipital white matter areas and the left temporal white matter area,leading to a diagnosis of reversible posterior leukoencephalopathy syndrome(RPLS).After discontinuing axitinib and giving symptomatic treatment,the patient's symptoms and imaging abnormalities completely disappeared within one week.This article analyzed a case of adverse reaction to axitinib that causes RPLS,aiming to draw clinical attention.

关 键 词：阿昔替尼 靶向治疗 可逆性后部脑白质病综合征 不良反应 

分 类 号：R741[医药卫生—神经病学与精神病学]