基于发育原理的牙颌再生与转化应用  

Dental and maxillofacial regeneration and translation based on developmental principles

作　　者：陈姝言 高晓彤 蒋文凯 隋秉东 CHEN Shuyan;GAO Xiaotong;JIANG Wenkai;SUI Bingdong(State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,National Clinical Research Center for Oral Diseases,Shaanxi Key Laboratory of Stomatology,Development Center for Tissue Engineering,The Third Hospital Affiliated of Air Force Military Medical University,Xi’an 710032,China;Department of Hematology,Tangdu Hospital,Air Force Medical University,Xi'an;Department of Operative Dentistry and Endodontics,The Third Hospital Affiliated of Air Force Military Medical University,Xi'an)

机构地区：[1]口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔医学重点实验室,空军军医大学第三附属医院组织工程研发中心,西安710032 [2]空军军医大学第二附属医院血液内科 [3]空军军医大学第三附属医院牙体牙髓病科

出　　处：《实用口腔医学杂志》2024年第6期741-746,共6页Journal of Practical Stomatology

基　　金：国家自然科学基金(编号:82371020,82270973,82200171);陕西省科技厅项目(编号:2023KJXX-027)。

摘　　要：在各类口颌系统疾病中,组织缺损的发病率高且危害大、形态与功能重建难,严重影响患者生理与心理健康。基于干细胞和组织工程技术的牙颌再生是实现牙颌缺损治疗的潜在途径,也是当前国际竞争的焦点。该文基于干细胞调控器官发育性形成的可能机制,回顾了当前牙颌再生与转化应用的现状,并提出该领域将来的发展方向,以期推动牙颌再生与转化研究的持续发展。In the various diseases of oral and maxillofacial system,the incidence of tissue defects is high and harmful,the reconstruction of the morphology and function is difficult,which seriously affects the physiological and mental health of the patients.Dental and maxillofacial regeneration based on stem cells and tissue engineering technology is a potential way for the treatment of dental and maxillofacial defects,and is also the focus of current international competition.Based on the possible mechanism of stem cells regulating organ development,this paper reviews the current status of dental and maxillofacial regeneration and translation,and proposes future direction in this field in order to promote the sustainable development of dental and maxillofacial regeneration and translation.

关 键 词：再生医学 缺损修复 干细胞 组织工程 牙 颅颌面 

分 类 号：R780.2[医药卫生—口腔医学]