唾液半乳糖凝集素-3与牙周炎分期的相关性分析  

Association between salivary galectin- 3 and periodontitis stage

作　　者：张彦表 夏天永 尹文婷 ZHANG Yanbiao;XIA Tianyong;YIN Wenting(Department of Periodontology,Shandong Second Medical University,China;Department of Periodontology,School of Stomatology,Shandong Second Medical University,Weifang 261042,China)

机构地区：[1]山东第二医科大学口腔医学院口腔内科学教研室,潍坊261042 [2]山东第二医科大学口腔医学院牙周病科,潍坊261042

出　　处：《实用口腔医学杂志》2024年第6期817-822,共6页Journal of Practical Stomatology

基　　金：山东省中医药发展计划项目(编号:2019-0436);山东第二医科大学公派教师国内访学项目(编号:2018-0415);山东省医药卫生科技发展计划项目(编号:2017WSB28007)。

摘　　要：目的:通过检测Ⅰ~Ⅲ期牙周炎患者唾液半乳糖凝集素-3(Gal-3)的水平探讨其与牙周炎分期的相关性。方法:采用横断面研究的方法,纳入Ⅰ、Ⅱ、Ⅲ期牙周炎患者各35例,同期选取牙周健康的志愿者35例为健康对照组。ELISA法检测静息状态下唾液Gal-3水平。对Gal-3与牙周炎分期的相关性进行统计学分析。结果:健康对照组及Ⅰ期、Ⅱ期、Ⅲ期牙周炎组唾液Gal-3的中位数[M(Q1,Q3)]水平(ng/mL)分别为89.40(84.56,96.58)、98.26(89.15,112.29)、136.22(116.21,144.33)和183.27(161.45,196.92),Jonckheere-Terpstra趋势检验显示,唾液Gal-3水平与牙周炎分期存在顺序效应(Z=10.178,P_(trend)<0.001)。Spearman相关分析显示,唾液Gal-3水平分别与PD、CAL、BI、BOP及PLI均呈显著正相关(P<0.001)。多元Logistic回归分析显示,校正了性别、年龄后,唾液Gal-3水平与Ⅰ、Ⅱ、Ⅲ期牙周炎均显著相关,校正优势比(aOR)分别为1.061(95%CI:1.016~1.108,P=0.008)、1.181(95%CI:1.105~1.202,P<0.001)、1.267(95%CI:1.177~1.365,P<0.001)。受试者工作特征(ROC)曲线分析显示,Gal-3预测Ⅰ、Ⅱ、Ⅲ期牙周炎的曲线下面积(AUC)分别为0.685(95%CI:0.167~0.524,P=0.005)、0.958(95%CI:0.167~0.524,P<0.001)和0.997(95%CI:0.942~1.000,P<0.001)。结论:唾液Gal-3水平与牙周炎分期显著相关,是反映牙周炎严重程度的潜在生物学标志物。Objective:To explore the association between salivary galectin-3(Gal-3)and periodontitis stage.Methods:For this cross-sectional study,35 patients for each periodontitis Stage I,II and III group were recruited,and 35 periodontally healthy subjects were included in the control group.Salivary level of Gal-3 was examined by ELISA.The association between Gal-3 and periodontitis stage was analyzed.Results:The median levels〔M(Q1,Q3),ng/mL〕of salivary Gal-3 in the healthy control group and the periodontitis StageⅠ,ⅡandⅢgroups were 89.40(84.56,96.58),98.26(89.15,112.29),136.22(116.21,144.33)and 183.27(161.45,196.92),respectively.Jonckheere-Terpstra trend test showed that there was a sequential effect between salivary Gal-3 level and the stage of periodontitis(Z=10.178,P_(trend)<0.001).Spearman's rank correlation analysis showed that the level of Gal-3 was positively correlated with PD,CAL,BI,BOP and PLI respectively(P<0.001).Multinomial logistic regression analysis showed that Gal-3 level was significantly associated with periodontitis StageⅠ,ⅡandⅢ,the adjusted odds ratio(aOR)were 1.061(95%CI:1.016-1.108,P=0.008),1.181(95%CI:1.105-1.202,P<0.001)and 1.267(95%CI:1.177-1.365,P<0.001),respectively.ROC curves showed that the AUCs of Gal-3 in the predicting stageⅠ,ⅡandⅢperiodontitis were 0.685(95%CI:0.167-0.524,P=0.005),0.958(95%CI:0.167-0.524,P<0.001)and 0.997(95%CI:0.942-1.000,P<0.001),respectively.Conclusion:Salivary Gal-3 level is significantly correlated with periodontitis stage,and it might be a potential biological marker for predicting periodontitis severity.

关 键 词：半乳糖凝集素-3 牙周炎 分期 相关性 

分 类 号：R781.4[医药卫生—口腔医学]