无托槽隐形矫治与固定矫治患者的龈沟液中C反应蛋白与IL-18、IL-37表达及其相关性研究  

Expression and correlation of CRP and IL-18,IL-37 in gingival crevicular fluid in the subjects treated with invisible correction without bracket and fixed aligners

作　　者：张震宇 马艳宁[1] 赵彬[3] ZHANG Zhenyu;MA Yanning;ZHAO Bin(Department of Orthodontics,Stomatological Hospital of Shanxi Medical University,Taiyuan 030001,China;Department of Prosthodontics,Stomatological Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学口腔医院正畸科,太原030001 [2]安徽医科大学附属亳州医院口腔科 [3]山西医科大学口腔医院修复科,太原030001

出　　处：《实用口腔医学杂志》2024年第6期823-828,共6页Journal of Practical Stomatology

基　　金：山西省卫生健康委科研课题(编号:2019109);山西省重点研发计划项目(编号:201803D121041)。

摘　　要：目的:探讨无托槽隐形矫治与固定矫治患者龈沟液(GCF)中C反应蛋白(CRP)与IL-18、 IL-37表达及其相关性。方法:纳入接受无托槽隐形矫治的10例患者作为实验组,接受固定矫治的12例患者作为对照组,ELISA法分别检测患者接受矫治前与接受矫治后24 h、 1个月、 3个月龈沟液中IL-18、 IL-37及CRP的表达水平。结果:正畸治疗前,两组GCF中IL-18、 IL-37及CRP表达水平差异无统计学意义(P>0.05);佩戴矫治器24 h,两组GCF中IL-18、 IL-37及CRP的表达水平均升高,实验组GCF中IL-18、 IL-37及CRP表达水平高于对照组(P<0.05);佩戴矫治器1个月,实验组GCF中IL-18、IL-37及CRP的表达水平低于对照组(P<0.05);佩戴矫治器3个月,组间差异,P>0.05。两组受试者GCF中CRP与IL-18、 IL-37水平呈正相关(P<0.001)。结论:隐形矫治矫治24 h内,由于高应力的刺激GCF中IL-18、 IL-37和CRP水平明显高于固定矫治,提示加力初期隐形矫治对牙周组织的影响可能大于固定矫治。Objective:To investigate the expression and correlation of C-reactive protein(CRP)with IL-18,IL-37 in gingival crevicular fluid(GCF)after invisible orthodontics treatment and fixed orthodontics treatment respectively.Methods:10 patients with invisible orthodontic treatment were included in the study group,and 12 patients with fixed orthodontic treatment were included in the control group.The expression levels of IL-18,IL-37 and CRP in GCF before,24 h,1 and 3 months after orthodontic treatment were detected by ELISA.Results:Before orthodontic treatment,there was no significant difference in the expression levels of IL-18,IL-37 and CRP in GCF between the 2 groups(P>0.05).The expression levels of IL-18,IL-37 and CRP in GCF increased at 24 h after treatment,and those in the study group were higher than in the control group(P<0.05).After 1 month of treatment,those in the study group were lower than in the control group(P<0.05).After 3 months of treatment,the expression levels of the factors were not statistically different between the 2 groups(P>0.05).The leves of CRP,IL-18 and IL-37 in GCF were positivelly correlated in both groups(P<0.001).Conclusion:The levels of IL-18,IL-37 and CRP in GFC in the subjects treated with invisible correction are increased due to high stress stimulation in a period of 24 hours,suggesting that the effect on the periodontal tissue by the invisible correction may be greater than that by the fixed correction.

关 键 词：隐形矫治 固定矫治 IL-18 IL-37 C反应蛋白 

分 类 号：R783.5[医药卫生—口腔医学]