牙周致病菌在不良妊娠发生发展中的作用研究  

Roles of periodontal pathogens in the adverse pregnancy

作　　者：贺姿慧 白新娜 刘斌杰 喻朝 唐茜(综述) 潘灏(审校) HE Zihui;BAI Xinna;LIU Binjie;YU Zhao;TANG Qian;PAN Hao(Department of Periodontics Section,Xiangya Stomatological Hospital&Xiangya School of Stomatology&Hunan Key Laboratory of Oral Health Research,Central South University,Changsha 410008,China;Department of Endodontics,Xiangya Stomatological Hospital&Xiangya School of Stomatology&Hunan Key Laboratory of Oral Health Research,Central South University,Changsha 410008,China;Department of Oral and Maxillofacial Radiology,Xiangya Stomatological Hospital&Xiangya School of Stomatology&Hunan Key Laboratory of Oral Health Research,Central South University,Changsha 410008,China)

机构地区：[1]湖南中南大学湘雅口腔医院·中南大学湘雅口腔医学院·口腔健康研究湖南省重点实验室牙周科,长沙410008 [2]湖南中南大学湘雅口腔医院·中南大学湘雅口腔医学院·口腔健康研究湖南省重点实验室牙体牙髓科,长沙410008 [3]湖南中南大学湘雅口腔医院·中南大学湘雅口腔医学院·口腔健康研究湖南省重点实验室放射科,长沙410008

出　　处：《实用口腔医学杂志》2024年第6期849-854,共6页Journal of Practical Stomatology

基　　金：国家自然科学基金(编号:5230130435);湖南省自然科学基金(编号:2021JJ40900);中南大学湘雅口腔医学院青年研究启动基金(编号:B2018002)。

摘　　要：牙周炎与全身健康特别是不良妊娠关系密切,牙周致病菌积极参与了宫内感染的形成与发展。研究显示牙周致病菌感染是不良妊娠事件的重要危险因素,牙周致病菌通过血行或逆行途径到达子宫,细菌、细菌的毒力因子及其导致机体产生的免疫炎症介质相互促进,共同介导宫内感染的发生发展并最终导致不良妊娠。文章对牙周炎及牙周致病菌在不良妊娠中的作用及其感染机制进行综述,为提高人口出生率提供新的可能性。Periodontitis is closely related to systemic health,especially adverse pregnancy.Periodontal pathogens are actively involved in the formation and development of intrauterine infections.Studies have shown that infection by periodontal pathogens is an important risk factor for adverse pregnancy.Periodontal pathogens reach the uterus via the hematogenous or retrograde route,and the bacteria,their virulence factors,and the immunoinflammatory mediators produced by the pathogens promote each other and together mediate the development of intrauterine infections and ultimately lead to adverse pregnancies.This article reviews the role of periodontitis and periodontal pathogens in adverse pregnancies and their mechanisms of infection to provide new possibilities for improving the birth rate.

关 键 词：牙周炎 不良妊娠 牙周致病菌 宫内感染 

分 类 号：R781.4[医药卫生—口腔医学]